Cytomegalovirus-associated colitis with colonic stricture mimicking necrotizing enterocolitis in a newborn: a case report

Nurdan Dinlen Fettah; Dilek Dilli; Aysegül Zenciroğlu; Gönül Tanır; Sema Apaydın; İ. Faruk Özgüner; Nurullah Okumuş

doi:10.18203/2349-3291.ijcp20161067

Authors

Nurdan Dinlen Fettah Department of Neonatology, Dr Sami Ulus Maternity and Children Training and Research Hospital, Ankara, Turkey
Dilek Dilli Department of Neonatology, Dr Sami Ulus Maternity and Children Training and Research Hospital, Ankara, Turkey
Aysegül Zenciroğlu Department of Neonatology, Dr Sami Ulus Maternity and Children Training and Research Hospital, Ankara, Turkey
Gönül Tanır Department of Pediatric Infectious Disease, Dr Sami Ulus Maternity and Children Training and Research Hospital, Ankara, Turkey
Sema Apaydın Department of Pathology, Dr Sami Ulus Maternity and Children Training and Research Hospital, Ankara, Turkey
İ. Faruk Özgüner Department of Pediatric Surgery, Dr Sami Ulus Maternity and Children Training and Research Hospital, Ankara, Turkey
Nurullah Okumuş Department of Neonatology, Dr Sami Ulus Maternity and Children Training and Research Hospital, Ankara, Turkey

DOI:

https://doi.org/10.18203/2349-3291.ijcp20161067

Keywords:

Cytomegalovirus, Necrotizing enterocolitis, Newborn

Abstract

Necrotizing enterocolitis is the most common gastrointestinal emergency in neonatal period. The etiology is considered multifactorial. Risk factors include prematurity, enteral feeding, hypoxia, and bacterial colonization. The etiologic role of viruses is unclear. Although cytomegalovirus (CMV) is a common congenital infection in neonates, most patients are asymptomatic. Gastrointestinal manifestation is unusual. In this report, we described a newborn with perinatal CMV infection presenting with symptoms mimicking necrotizing enterocolitis.

Metrics

Metrics Loading ...

References

Gregory KE, DeForge CE, Natale KM. Necrotizing Enterocolitis in the Premature. Infant. Adv Neonatal Care. 2011;11:155-66.

Kenneson A, Cannon M. Review and meta-analysis of the epidemiology of congenital cytomegalovirus (CMV) infection. Rev Med Virol. 2007;17:253-76.

Cheong JL, Cowan FM, Modi N. Gastrointestinal manifestations of postnatal cytomegalovirus infection in infants admitted to a neonatal intensive care unit over a five year period. Arch Dis Child Fetal Neonatal Ed. 2004;89:367-9.

Sheikha AR, Ghazala B, Ionescu G, Uduman SA. Congenital cytomegalovirus associates with intestinal stricture and small bowel obstruction presented in early infancy. J Pediatr Surg Specialties. 2009;3:27-9.

Bar-Meir M, Farrow KN, Melin-Aldana H, Chadwick EG. Cytomegalovirus Enterocolitis Mimicking Necrotizing Enterocolitis: Case Reports and Review of the Literature. J Pediatric Infect Dis Soc. 2013;2:71-5.

Lee SL, Johnsen H, Applebaum H. Cytomegalovirus enterocolitis presenting as abdominal compartment syndrome in a premature neonate. World J Pediatr. 2012;8:80-2.

Reyes C, Pereira S, Warden MJ, Sills J. Cytomegalovirus enteritis in a premature infant. J Pediatr Surg. 1997;32:1545-7.

Marseglia L, Manti S, D'Angelo G, Lima M, Impellizzeri P, Romeo C. Colonic stenosis post-necrotizing enterocolitis in term newborn with acquired cytomegalovirus infection. Chirurgia (Bucur). 2015;110:175-8.

Tran L, Ferris M, Norori J, Stark M, Craver R, Dowd S. Necrotizing enterocolitis and cytomegalovirus infection in a premature infant. Pediatrics. 2013;131:e318-22.

Skeath T, Stewart C, Waugh S, Embleton N, Cummings S, Berrington J. Cytomegalovirus and other common enteric viruses are not commonly associated with NEC. Acta Paediatr. 2015.