DOI: http://dx.doi.org/10.18203/2349-3291.ijcp20200688

Clinical and laboratory profile of children with dengue fever admitted at a tertiary care hospital in Mangalore, Karnataka, India: a retrospective study

Tejaswini M., Sahana K. S., Prakash R. M. Saldanha

Abstract


Background: Dengue fever caused by dengue virus is a self-limiting acute febrile illness transmitted by Aedes aegypti, a daytime biting mosquito. Dengue virus belongs to family of Flaviviridae and there are 4 serotypes. A fifth serotype DENV-5 was isolated in 2013 which was said to cause mild form of the disease. In 2019 total numbers of dengue cases are 10,524 in Karnataka which is 138% increase over 2018 (4,427 cases).

Methods: A retrospective conducted in Yenepoya Medical College hospital from January 2017 to July 2019 for a period of 2½ years. Medical records of children who were diagnosed with dengue fever were retrieved and analyzed. Clinical and laboratory findings were noted down. Clinical course and outcome were noted down from the case sheet and cases were classified as per WHO 2011 classification.

Results: 97 children diagnosed with dengue fever were included in the study. Common age group was 5-15 years. 49.5% had dengue fever, 40.2% had dengue haemorrhagic fever (DHF) and 10.3% had expanded dengue syndrome. Fever was the main complaint. Children with dengue fever presented with vomiting, abdominal pain, myalgia, arthralgia in descending order of frequency. Children with DHF, petechiae were seen in 38% patients. Among bleeding manifestations, epistaxis was more common. Children with expanded dengue syndrome had atypical manifestations.

Conclusions: Dengue fever like any other viral illness, presents with prodromal symptoms which should be picked up at the earliest with high index of suspicion in children coming from endemic area. Identification of atypical manifestations and co-infections at the earliest and prompt treatment avoids serious life-threatening complications.


Keywords


Dengue fever, Dengue WHO 2011 classification, Dengue haemorrhagic fever, Dengue in children

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References


Bhatt S, Gething PW, Brady OJ, Messina JP, Farlow AW, Moyes CL, et al. The global distribution and burden of dengue. Nature. 2013;496(7446):504-7.

Dengue Takes 6 Lives in Karnataka, 10, 524 Cases Reported Since January. Available at: https://india.timesofnews.com/political/political/dengue-takes-6-lives-in-karnataka-10-524-cases-reported-since-january.html

Mustafa MS, Rasotgi V, Jain S, Gupta V. Discovery of fifth serotype of dengue virus (DENV-5): A new public health dilemma in dengue control. Med J Armed Forces India. 2015;71(1):67-70.

Degnue: Guidelines for diagnosis, treatment, prevention and control. World Health Organization. Geneva, Switzerland: WHO;2011.

Jain H. Clinical profile and outcome of dengue fever in hospitalized children of South Rajasthan, India. Int J Contemp Paediatr. 2016;3:546-9.

Sahana KS, Sujatha R. Clinical profile of dengue among children according to revised WHO classification: analysis of a 2012 outbreak from Southern India. Indian J Paediatr. 2015;82(2):109-13.

Mishra S, Ramanathan R, Agarwalla SK. Clinical profile of dengue fever in children: A study from Southern Odisha, India. Scientifica. 2016;2016.

Pothapregada S, Kamalakannan B, Thulasingam M. Clinical profile of atypical manifestations of dengue fever. Indian J Pediatr. 2016;83(6):493-9.

Kumar SK, Rajendran NK, Brabhukumar AC. Clinical profile of dengue fever in children: analysis of 2017 outbreak from central Kerala. Int J Contemp Paediatr. 2018;5:2265-9.

Ahmed S, Arif F, Yahya Y. Dengue fever outbreak in Karachi 2006- a study of profile and outcome of children under 15 years of age. J Pak Med Assoc. 2008;58(1):4-8.

Balmaseda A, Hammond SN, Pérez MA, Cuadra R, Solano S, Rocha J, et al. Assessment of the World Health Organization scheme for classification of dengue severity in Nicaragua. Am J Trop Med Hygiene. 2005;73(6):1059-62.

Faridi MM, Aggarwal A, Kumar M, Sarafrazul A. Clinical and biochemical profile of dengue haemorrhagic fever in children in Delhi. Trop Doct. 2008;38(1):28-30.

Narayanan M, Aravind MA, Thilothammal N, Prema R, Sargunam CR, Ramamurty N. Dengue fever epidemic in Chennai-a study of clinical profile and outcome. Indian Pediatr. 2002;39(11):1027-33.

Ratageri VH, Shepur TA, Wari PK, Chavan SC, Mujahid IB, Yergolkar PN. Clinical profile and outcome of dengue fever cases. Indian J Pediatr. 2005;72(8):705-6.

Gulati S, Maheshwari A. Atypical manifestations of dengue. Tropical Med Int Health. 2007;12:1087-95.

Lum LC, Thong MK, Cheah YK, Lam SK. Dengue associated adult respiratory distress syndrome. Ann Trop Paediatr. 1995;15:335-9.

Verma R, Sharma P, Garg RK, Atam V, Singh MK, Mehrotra HS. Neurological complications of dengue fever: experience from a tertiary centre of North India. Ann Indian Acad Neurol. 2011;14:272-8.