Published: 2020-02-25

A clinico-etiological evaluation of neonatal seizures in a tertiary care hospital: a prospective cohort study

Kuldeep Kumar Sharma, Shifa Bidhan, Sandeep D. Paimode


Background: Neonatal seizure is defined as a paroxysmal alteration in neurological function. The diagnosis of neonatal seizures is difficult to establish because of varied etiologies involved. The incidences vary from 1.5-3.7/1000 live births in term babies.

Methods: Hospital based observational Study was conducted from December 1, 2016 till March 31, 2018. Universal sampling technique was followed. 93 neonates fulfilling the inclusion criteria were included in the study after consent from parents.

Results: Present study results showed that 60.2% were males. Pre-term delivery occurred in 12.9% neonates. Most common etiology of neonatal seizures was birth asphyxia with 47.3% followed by metabolic abnormalities 32.3%.

Conclusions: The most common etiology for neonatal seizures was birth asphyxia followed by metabolic abnormalities in which hypoglycaemia was the most common type. A significant association of seizures due to meningitis and metabolic abnormalities was observed with pre-term gestation.


Birth asphyxia, Neonates, Pre-term, Seizures

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Sankar MJ, Agarwal R, Aggarwal R, Deorari AK, Paul VK. Seizures in the newborn. Indian J Pediatr. 2008;75(2):149-55.

Zupanc ML. Neonatal seizures. Pediatr Clin N Am. 2004;51:961-78.

Volpe JJ. Hypoxic-Ischemic Encephalopathy: Biochemical and Physiological Aspects. In: Neurology of the Newborn. 4th ed. Philadelphia: WB Saunders; 2000:217-276.

Gregory HL, Roustem K, Yehezkiel B. New concepts in neonatal seizures. Neuroreport. 2002;31:A3-8.

Moayedi AR, Zakeri S, Moayedi F. Neonatal seizure: etiolgy and type. Iran J Child Neurol. 2008;23-26.

Eghbalian F, Monsef A, Taghdiri MM. Neonatal seizures: etiology and frequency. Iran J Child Neurol. 2008;39-42.

Digra SK, Gupta A. Prevalence of seizures in hospitalized neonates. JK Sci. 2007;9:27-29.

Parvin R, Salim AF, Rahman M, Chowdhury K, Sultana A, Ahmed S, et al. Neonatal seizures: correlation between clinico-etiological profile and EEG findings. Bangladesh J Child Health. 2014;38(1):19-23.

Marzoki JMA. Clinico-Biochemical profile of neonatal seizures (Research Thesis). Hilla-Iraq- Babylon: Babylon University; 2009.

Kumar A, Gupta A, Talukdar B. Clinico-etiological and EEG profile of neonatal seizures. Indian J Pediatr. 2007;74(1):33-7.

Arun S. Clinical profile of seizures in neonatal intensive care unit. In: Fernandez AH, Dadhich JPP, Saluja YS, Eds, Abstracts, XXIII Annual. Convention of National Neonatology Forum, Dec. 18-21, 2003; Hyderabad. 2003:109-11.

Ronen GM, Penney S, Andrews W. The epidemiology of clinical neonatal seizures in Newfoundland: a population-based study. J Pediatr. 1999;134(1):71-5.

Brunquell PJ, Glennon CM, DiMario FJ Jr, Lerer T, Eisenfeld L. Prediction of outcome based on clinical seizures type in newborn infants. J Pediatr. 2002;140:707-12.

Mahaveer L, Vilhekar KY, Chaturvedi P. Clinico-biochemical profile of neonatal seizures in a rural medical college. In: Fernandez AIH, Dadhich JPP, Saluja YS, Editors, Abstracts, XXIII Annual Convention of National Neonatology Fornum, Dec. 18-21, 2003; Hyderabad. 2003:121-122.

Madhusudhan K, Suresh NS, Babu TR, Rao JV, Kumar SB. Study of biochemical abnormalities in neonatal seizures with special reference to hyponatremia. Int J Contemp Pediatr. 2016;3(3):730-4.