DOI: http://dx.doi.org/10.18203/2349-3291.ijcp20161049

Prevalence and clinical profile of mycoplasma pneumoniae respiratory infection in children: a hospital based study

Carol Sara Cherian, Thushara S. Nair, Sushama Bai S., Seema Oommen

Abstract


Background: Mycoplasma pneumoniae (M. pneum) is a well-established cause of respiratory tract infections in the pediatric population worldwide. This study aimed to assess the prevalence and clinical profile of children with mycoplasma respiratory infection.

Methods: Design was prospective study. Departments of Pediatrics and Microbiology of Tertiary care Medical College. Study period was one year (Jan 2012 to Dec 2012). Children (age 3 months to 15 yrs) with respiratory tract infection symptoms of >5 days. Histories, physical examination, routine lab investigations of respiratory infection, IgM ELISA for Mycoplasma pneumoniae (M. pneum) were done. Treatment Initiated as per ARI guidelines with appropriate modifications. M. peum cases were additionally treated with azithromycin. Response assessed clinically and by investigations. Statistical analysis was done by chi-square and t-tests.

Results: Prevalence of M. pneum. respiratory infection was 22.44%. Clustering of positive cases was during the pre-monsoon and monsoon seasons. Fever, sore throat and consolidation revealed significant association with M pneu-infection clinically. High ESR and absence of leucko cytosis were the significant lab parameters of M. pneum positive cases. All positive cases responded to arithromycin. There was no mortality.

Conclusions: M. pneum contributes to 22.44% respiratory infections in hospital attending children. Fever, sore throat consolidation and high ESR are the significant suggestive parameters.


Keywords


Mycoplasma pneumoniae, Sorethroat, Consolidation, IgM ELISA, ESR, Azithromycin

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References


Kabra SK, Verma IC. Acute respiratory tract infection a forgotten entity. Indian J Pediatr. 1999;66:873-5.

Kliegman RM, Stanton BF, Schor NF, St. Geme JW, Behrman RE. Nelson textbook of pediatrics. 19th edition Philadelphia, Saunders. 2011:1029-32.

Waris ME, Toikka P, Saarinen T, Nikkari S, Meurman O, Vainionpaa R, et al. Diagnosis of Mycoplasma pneumoniae pneumonia in children. J Clin Microbiol. 1998;36(11):3155-9.

Jacobs E. Serological diagnosis of Mycoplasma pneumoniae infections: acritical review of current procedures. Clin Infect Dis. 1993;(1):S79-82.

Kashyap B, Kumar S, Sethi GR, Das BC, Saigal SR. Comparison of PCR, culture & serological tests for the diagnosis of Mycoplasma pneumoniae incommunity acquired lower respiratory tract infections in children. Indian J Med Res. 2008;128(2):134-9.

Shenoy VD, Upadhyaya SA, Rao SP, Shobha KL. Mycoplasma pneumonia infection in children with acute respiratory infection. J Trop Pediatr. 2005;51:232-5.

Chaudhry R, Nazima N, Dhawan B, Kabra SK. Prevalence of Mycoplasma pneumoniae and chlamydia pneumoniae in children with community acquired pneumonia. Indian J Pediatr. 1998;65:717-21.

Youn YS, Lee KY, Hwang JY, Rhim JW, Kang JH, Lee JS, et al. Difference of clinical features in childhood Mycoplasma pneumoniae pneumonia. BMC Pediatr. 2010;10:48.

Gavranich JB, Chang AB. Antibodies for community acquired lower respiratory tract infections secondary to M. pneumoniae in children. Cochrane Database Syst Rev. 2005;3:CD004875.

Jensen JS, Sondergard-Andersen J, Uldum SA, Lind

K. Detection of Mycoplasma pneumoniae in simulated clinical samples by polymerase chain reaction. Brief report. APMIS. 1989;97(11):1046-8.

Saito R, Misawa Y, Moriya K, Koike K, Ubukata K, Okamura N. Development and evaluation of a loop-mediated isothermal amplification assay for rapid detection of Mycoplasma pneumoniae. J Med Microbiol. 2005;54(11):1037-41.

Daxboeck F, Khanakah G, Bauer C, Stadler M, Hofmann H, Stanek G. Detection of Mycoplasma pneumoniae in serum specimens from patients with mycoplasma pneumonia by PCR. Int J Med Microbiol. 2005;295(4):279-85. Erratum in: Int J MedMicrobiol. 2006;296(1):55.

World Health Organisation. Antibiotics in treatment of acute respiratory infection in children. Unpublished document WHO/ARI/90.10, available on request from the division of child health and development, formerly the division of diarrhoeal and acute respiratory disease control, WHO, Geneva. 1990.

Kabra SK, Lodha R, Broor S, Chaudhary R, Ghosh M, Maitreyi RS. Etiology of acute lower respiratory tract infection. Indian J Pediatr. 2003;70(1):33-6.