Neonatal outcome of a giant placental chorioangioma in a late preterm newborn

Daniel Nigri, Hicham Dabaja, Alyosha Smolarski, Lourdes Cohen


Chorioangioma, the most common benign placental tumor, is found in 1% of placental pathology. Tumors greater than 4 cm are classified as giant and associated with multiple maternal and fetal complications. Authors are presenting a case report of a rare 16 cm giant chorioangioma, discovered at time of delivery, complicated with pregnancy induced hypertension and presenting with minimal fetal complication. This patient exhibited eventually a satisfactory perinatal outcome, complicated by severe anemia and thrombocytopenia requiring transfusion of blood products and bilateral, self-resolved spontaneous cephalohematomas. Chorioangiomas should be considered in the differential diagnosis of any newborn that presents with anemia.


Anemia, Cephalohematoma, Chorioangioma, Newborn

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Al Wattar BH, Hillman SC, Marton T, Foster K, Kilby MD. Placenta chorioangioma: a rare case and systematic review of literature. J Maternal-Fetal Neonat Med. 2014;27(10):1055-63.

Fan M, Skupski DW. Placental chorioangioma: literature review. J Perinat Med. 2014;42(3):273-9.

Sepulveda W, Alcalde JL, Schnapp C, Bravo M. Perinatal outcome after prenatal diagnosis of placental chorioangioma. Obstetr Gynecol. 2003;102(5):1028-33.

Buca D, Iacovella C, Khalil A, Rizzo G, Sirotkina M, Makatsariya A. Perinatal outcome of pregnancies complicated by placental chorioangioma: a systematic review and meta‐analysis. Ultrasound Obstetr Gynecol. 2019.

Abdalla N, Bachanek M, Trojanowski S, Cendrowski K, Sawicki W. Placental tumor (chorioangioma) as a cause of polyhydramnios: a case report. IntJ Women's Health. 2014;6:955.

Abiramalatha T, Sherba B, Joseph R, Thomas N. Unusual complications of placental chorioangioma: consumption coagulopathy and hypertension in a preterm newborn. BMJ Case Rep. 2016;2016.

Jhun KM, Nassar P, Chen TS, Sardesai S, Chmait RH. Giant chorioangioma treated in utero via laser of feeding vessels with subsequent development of multifocal infantile hemangiomas. Fetal Pediatr Pathol. 2015;34(1):1-8.

Willis C, Ferguson S, Soydemir F. Placental chorioangioma associated with polyhydramnios and hydrops fetalis. BMJ Case Rep CP. 2019;12(1).

Haak MC, Oosterhof H, Mouw RJ, Oepkes D, Vandenbussche FP. Pathophysiology and treatment of fetal anemia due to placental chorioangioma. Ultrasound in Obstetrics and Gynecology: The Official J Int Soci Ultrasound Obstetr Gynecol. 1999;14(1):68-70.

Sepulveda W, Wong AE, Herrera L, Dezerega V, Devoto JC. Endoscopic laser coagulation of feeding vessels in large placental chorioangiomas: report of three cases and review of invasive treatment options. Prenat Diag. 2009;29(3):201-6.

García-Díaz L, Carreto P, Costa-Pereira S, Antiñolo G. Prenatal management and perinatal outcome in giant placental chorioangioma complicated with hydrops fetalis, fetal anemia and maternal mirror syndrome. BMC Preg Childbirth. 2012;12(1):72.

He XH, Zhou HJ, Zheng W. Clinical characteristics and pathologic study of placental chorioangioma. Zhonghua fu chan ke za zhi. 2004;39(4):227-9.