Email this article Study on electrolyte disturbances in dengue fever in a tertiary care centre
Abstract
Background: Dengue is a mosquito borne disease of significant morbidity and mortality. Dengue viral infection has been shown to be associated with electrolyte abnormalities and renal dysfunction. It is necessary to have a thorough understanding about electrolyte disturbances in Dengue, so as to predict, diagnose and treat them accordingly. The aim and objective of this study is to study electrolyte disturbances in dengue fever and its correlation with severity of dengue fever.
Methods: This study was performed in a tertiary care centre in Bangalore , India. The study was a prosspective observational study. 200 Patients diagnosed with Dengue were enrolled for the study. Patients demographic data, clinical history, electrolyte values were recorded and analysed.
Results: In our study majority of patients belonged to 5-12 years age group ie 47%. Fever was found to be the most common presentation in 196 patients (98%) followed by myalgia in 142 patients (71%), headache in 102 patients (51%), skin rash in 43 patients (21.5%). The mean value of serum sodium observed was 133.69 mEq/L and of serum potassium was 3.58 mEq/L and there was positive and significant correlation between difference in serum sodium and potassium levels with severity of dengue fever.
Conclusions: Dyselectrolytemia is more common in dengue fever. Serum electrolytes testing early is very important in dengue patients during management so that if abnormalities are found, they can be appropriately managed as some of these abnormalities may lead to increased severity as well as mortality.
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World Health Organization. Dengue guidelines for diagnosis, treatment, prevention and control new edition. Geneva, 2009. Available at: http://www. who.int/rpc/guidelines/9789241547871/en/.
Lima EQ, Nogueira ML. Viral hemorrhagic fever-induced acute kidney injury. Semin Nephrol. 2008; 28(4):409-15.
Lumpaopong A, Kaewplang P, Watanaveeradej V, Thirakhupt P, Chamnanvanakij S, Srisuwan K, et al. Electrolyte disturbances and abnormal urine analysis in children with dengue infection. Southeast Asian Journal of Tropical Med and Public Health. 2010 Jan 1;41(1):72.
Mekmullica J, Suwanphatra A, Thienpaitoon H, Chansongsakul T, Cherdkiatkul T, Pancharoen C, et al. Serum and urine sodium levels in dengue patients. Southeast Asian J Trop Med Public Health. 2005 Jan;36(1):197-9.
Rose C. palani samy A, Vijaya ram H. Electrolyte disturbance in Dengue infected patients in Salem, Tamil nadu. Int J advances in Pharmacy, biology and Chemistry. 2014 Oct;3(4):933-6.
Hira HS, Kaur A, Shukla A. Acute neuromuscular weakness associated with dengue infection. Journal of neurosciences in rural practice. 2012 Jan;3(1):36
Adrogué HJ, Madias NE. The challenge of hyponatremia. J Am Soc Nephrol. 2012;23(7):1140-48.
Murthy J. Neurological complications of dengue infection. Neurol India 2010;58;581-84.
Khandelwal VG, Patil VC, Botre A, Patil R. Study of Electrolyte Disturbances in Dengue Infected Patients. Intern J Contemp Medical Research. 2019;6(2):B5-8.
Unnikrishnan R, Faizal BP, Vijayakumar P, Paul G, Sharma RN. Clinical and laboratory profile of dengue in the elderly. J Fam Med Prim care 2015;4(3):369-72.
Widodo D, Setiawan B, Chen K, Nainggolan L, Santoso WD. The prevalence of hypokalemia in hospitalized patients with infectious diseases problem at Cipto Mangunkusumo Hospital, Jakarta. Acta Med Indones. 2018;38:202-5.
Kalita J, Misra UK, Mahadevan A, Shankar SK. Acute pure motor quadriplegia: is it dengue myositis? Electromyogr Clin Neurophysiol 2018; 45:357-61.
Arun Gogna, Sitla Pathak, Kamakshi Dhamija, changing clinic hanging clinical profile of dengue Profile of dengue fever in Delhi in 2011. JIACM 2015;16:20-6.
