A study on correlation of gall bladder wall thickness with severity of Dengue fever

Authors

  • Vijayalakshmi A. Department of Pediatrics, Niloufer Hospital, Hyderabad, Telangana, India
  • Sreelekha P. Department of Pediatrics, Niloufer Hospital, Hyderabad, Telangana, India
  • Kalashankar D. Department of Pediatrics, Niloufer Hospital, Hyderabad, Telangana, India

DOI:

https://doi.org/10.18203/2349-3291.ijcp20194719

Keywords:

Dengue fever, Early predictor, Epidemics, Gallbladder wall thickness, Outcome, Severity

Abstract

Background: Dengue is an acute viral infection with potentially fatal complications. This study was done to describe the correlation of Gall bladder wall thickness with severity of Dengue fever and to predict the fatal outcome of Dengue fever at the earliest to prevent serious consequences by timely interventions.

Methods: This was a hospital based prospective observational study conducted at Niloufer Hospital, a tertiary care pediatric hospital attached to Osmania Medical College, Hyderabad, Telangana, India from October 2017 to November 2018. All children between 1 year to 12 years of age that had clinical features of dengue and who were serologically confirmed were included in this study.

Results: Age group most commonly affected was 5-8 years with maximum number of dengue cases without warning signs (55.7%). Majority of severe dengue cases (64.3%) had gall bladder wall thickness >5mm. The correlation between severity of dengue and gall bladder wall thickness was found to be highly significant indicating the higher the severity of dengue more the gall bladder thickness.

Conclusions: This study concludes gallbladder wall thickness (GBWT) measured by ultrasonography can be used in children for early prediction of the severity of DHF in children and authors can include gall bladder wall thickness as an admission criteria during epidemics.

References

Halstead SB. Antibody, macrophages, dengue virus infection, shock, and hemorrhage: a pathogenetic cascade. Rev Infect Dis. 1989;11(Supplement_4):S830-9.

Bhatt S, Gething PW, Brady OJ, Messina JP, Farlow AW, Moyes CL et.al. The global distribution and burden of dengue. Nature; 2013:496(7446):504-7.

Mishra S, Ramanathan R, Agarwalla SK. Clinical profile of dengue fever in children: a study from southern Odisha, India. Scientifica. 2016;2016.

Selvan T, Kumar PS, Giridhar, Swamy N, Kumar M. A Study of Current Outbreak of Dengue Fever in Children. JMSCR. 2015:03(08);7017-21.

Singh R, Singh SP, Ahmad N. A study of clinical and laboratory profile of dengue fever in a tertiary care centre of Uttarakhend, India. Int J Res Med Sci. 2014;2(1):160-63.

Jain H. Clinical profile and outcome of dengue fever in hospitalized children of South Rajasthan, India. Int J Contemp Pediatr. 2016;3(2):546-9.

Parmar JP, Mohan C, Vora M. Patterns of Gall Bladder Wall Thickening in Dengue Fever: A Mirror of the Severity of Disease. Ultrasound Int Open. 2017;3(2):E76–81.

Mogra G, Gulati Ghildiyal R, Mohanlal S. Classification and study of the clinico-hematological profile of patients with dengue fever in the pediatric age group. Int J Contemp Pediatr. 2016;3(4):1405-10.

Lum LC, Suaya JA, Tan LH, Sah BK, Shepard DS. Quality of life of dengue patients. Am J Tropical Med Hygiene. 2008;78(6):862-7.

Colbert JA, Gordon A, Roxelin R, Silva S, Silva J, Rocha C, Harris E. Ultrasound measurement of gallbladder wall thickening as a diagnostic test and prognostic indicator for severe dengue in pediatric patients. Pediatr Infec Dis J. 2007;26(9):850-2.

Setiawan MW, Samsi TK, Wulur H, Sugianto D, Pool TN. Dengue haemorrhagic fever: ultrasound as an aid to predict the severity of the disease. Pediatr Radiol. 1998;28(1):1-4.

Setiawan MW, Samsi TK, Pool TN, Wulur H. Gallbladder wall thickening in dengue hemorrhagic fever: an ultrasonographic study. J Clin Ultrasound. 1995;23(6):357-62.

Downloads

Published

2019-10-21

Issue

Section

Original Research Articles