DOI: http://dx.doi.org/10.18203/2349-3291.ijcp20193687

Clinico-hematological profile of children with Dengue and co-infection with Malaria: a hospital based study

Ayesha Ahmad, Iraj Alam Khan, Mohammad Raza

Abstract


Background: The two most common vector borne diseases in the world are malaria and dengue. Co-infection infection is not unusual in a geographical region such as India, wherein both the vectors coexist. This study aimed to determine whether simultaneous malaria and dengue infection is serious in children than mono infection alone.

Methods: In this study all children with fever of less than 7 days duration were included in the study. Clinical inspection and laboratory analysis were performed in all instances, following a detailed history. Children were categorized under 3 categories, malaria (M), dengue (D) and coinfection (DM). For any statistical difference between groups, their clinical as well as hematological parameters were analyzed. SPSS software was used for the statistical studies.

Results: Malarial chills fever was also found in a substantial percentage of children with dengue. Superficial as well as profound bleeding were seen more often in the coinfected DM groups than D or M alone. In M group alone, jaundice and diarrhea were noted. In the segregated M and DM groups, the neurological indication, neurological involvement such as altered sensorium and seizure was noted at the same rate, whereas, there had been no occurrence in D group. Anemia was reported in all children, but M group showed the highest drop.

Conclusions: Severity criteria, neurological involvement such as altered sensorium and seizures were reported at same rate both in malaria and coinfection, whereas, none of the patients with dengue showed signs of seizure. Anemia relative to hematologic parameters, was considerably more prevalent in the malaria patients. Presence of bleeding in malaria and jaundice in dengue patients, should be considerably investigated for a coinfection.


Keywords


Coinfection in children, Dengue, Hematological parameters, Malaria, Neurological manifestation, Vector-borne diseases

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References


Raj AS, Munshi S, Shah BH. A study on clinical presentation of dengue fever in children. studies. 2016;21(22):23.

Bhat R, Varma C, Bhatt S. Dengue fever with co-infections: A case series in children. J Microbiol Infectious Diseases. 2014(1):S62-4.

National Guidelines for Clinical Management of Dengue Fever. National Vector Born Disease Control Programme, 2015.

World Health Organization Guidelines for the Treatment of Malaria, 2015.

Available at: https://www.who.int/malaria/publications/atoz/9789241549127/en/Diagnosis and Treatment by Directorate of National Vector Borne Disease Control Programme, 2014.

Magalhaes BML, Siqueria AM, Alexandre MAA. P. vivax malaria and Dengue Fever coinfection: A cross-sectional study in the Brazilian Amazon. PLOS Negr Trop Dis. 2014;8(10):e3239.

Barua A, Gill N. A comparative study of Concurrent Dengue and Malaria infection with their Monoinfection in a Teaching Hospital in Mumbai. Journal of The Association of Physicians of India, 2016;64(8):49-52.

Rao MRK, Padhy RN, Das NK. Prevalence of dengue viral and parasitic coinfections in an epidemic district, Angul of Odisha, India: An eco-epidemiological and cross sectional study for the prospective aspects of public health. Journal of Infection and Public Health, 2016;9(4):421-8.

Abbasi A, Butt N, Sheikh QH, Bhutto AR, Munir SM, Ahmed SM. Clinical features, diagnostic techniques and management of dual dengue and malaria infection. J Coll Physicians Surg Pak. 2009 Jan 1;19(1):25-9.

Mohapatra MK, Patra P, Agarwala K. Manifestation and outcome of concurrent malaria and dengue infection. J Vector Borne Disease, 2012;49(4):262-5.

Epolboin LC, Hanf M, Dussart P. Is dengue and malaria coinfection more severe than single infection? A retrospective matched-pair study in French Guiana. Malaria, 2012;11:142.

Assir MK, Masood MA, Ahmad HI. Concurrent dengue and malaria infection in Lahore, Pakistan during the 2012 dengue outbreak. Int J of Inf Dis. 2014;18:41-6.

Carme B, Matheus S, Donutil G, Raulin O, Nacher M, Morvan J. Concurrent dengue and malaria in Cayenne hospital, French Guiana. Emerging infectious diseases. 2009 Apr;15(4):668.

Yeolekar ME, Barua A, Sukumaran S. Changing profile of p. vivax malaria. Int J of Inf Dis. 2014;215:1460.

Yeolekar ME, Trivedi TH. Febrile Encephalopathy - challenges in management. J Assoc Physicians India, 2016;54:845-7.