DOI: http://dx.doi.org/10.18203/2349-3291.ijcp20193743

Evaluation of thyroid nodule in pediatric population in a tertiary care hospital

Mukul Singh, Manju Kumari

Abstract


Background: Thyroid nodules are commonly present in adult population but are rare in pediatric age group. Inspite of being rare, thyroid nodule have a higher chance of malignancy in children. Thus, pediatric patients presenting with thyroid nodule found clinically or incidentally should be worked up to rule out any possibility of malignancy. The besthesda system for reporting thyroid cytopathology (TBSRTC) is widely used for reporting in adults. The present study aims to use TBSRTC for pediatric thyroid lesions reporting.

Methods: All pediatric patients with age ≤ 18 years presenting with thyroid nodule during January 2018 to April 2019 were included in the study, fine needle aspiration (FNA) was done and findings were compared with histology. Statistical analysis was done using SPSS version 18.

Results: 42 pediatric patient were included in the study, out of which 2.38% were malignant and suspicious for nmalignant each and 83% were benign.

Conclusion: TBSRTC is quite sensitive and specific reporting guideline in pediatric population as in adult population with 100% accuracy in diagnosing benign and malignant cases. This is useful for avoiding unnecessary surgeries.


Keywords


Cytopathology, Malignancy, Pediatric, The besthesda system for reporting thyroid cytopathology, Thyroid nodule

Full Text:

PDF

References


Huang SA, Thyromegaly. In: Lifshitz, editor. Pediatric Endocrinology. 5th Ed. New York: Informa Healthcare; 2007;443-453.

Huang SA, Brown RS. The thyroid and its disorder. In: Brook C, Clayton P, Brown R, editors. Clinical Pediatric Endocrinology. 5th ed. USA: Blackwell; 2005:18-53.

Gupta A, Ly S, Castroneves LA, Frates MC, Benson CB, Feldman HA et al. A standardized assessment of thyroid nodules in children confirms higher cancer prevalence than in adults. J Clin Endocrinol Metab. 2013;98(8):3238-45.

Gharib H, Papini E, Valcavi R, Baskin HJ, Crescenzi A, Dottorini ME, et al. American Association of Clinical Endocrinologists and Associazione Medici Endocrinologi medical guidelines for clinical practice for the diagnosis and management of thyroid nodules. Endocr Pract. 2006;12(1):63-102.

Avula S, Daneman A, Navarro OM, Moineddin R, Urbach S, Daneman D. Incidental thyroid abnormalities identified on neck US for non-thyroid disorders. Pediatr Radiol. 2010;40:1774-80.

Hamberger B, Gharib H, Melton LJ 3rd, Goellner JR, Zinsmeister AR. Fine-needle aspiration biopsy of thyroid nodules. Impact on thyroid practice and cost of care. Am J Med. 1982;73:381-4.

Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, Mandel SJ, et al. American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer. Revised American Thyroid Association (ATA) Guidelines for patients with Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid. 2009;19:1167-214.

Al-Shaikh A, Ngan B, Daneman A, Daneman D. Fine-needle aspiration biopsy in the management of thyroid nodules in children and adolescents. J Pediatr. 2001;138(1):140-2.

Belfiore A, Giuffrida D, La Rosa GL, Ippolito O, Russo G, Fiumara A, et al. High frequency of cancer in cold thyroid nodules occurring at young age. Acta Endocrinol. (Copenh) 1989;121:197-202.

Hoperia V, Larin A, Jensen K, Bauer A, Vasko V. Thyroid fine needle aspiration biopsies in children: Study of cytological-histological correlation and immunostaining with thyroid peroxidase monoclonal antibodies. Int J Pediatr Endocrinol. 2010;2010:690108.

Bargren AE, Meyer-Rochow GY, Sywak MS, Delbridge LW, Chen H, Sidhu SB. Diagnostic utility of fine-needle aspiration cytology in pediatric differentiated thyroid cancer. World J Surg. 2010;34(6):1254-60.

Monaco SE, Pantanowitz L, Khalbuss WE, Benkovich VA, Ozolek J, Nikiforova MN, et al. Cytomorphological and molecular genetic findings in pediatric thyroid fine-needle aspiration. Cancer Cytopathol. 2012;120(5):342-50.

Monaco SE, Pantanowitz L, Khalbuss WE, Benkovich VA, Ozolek J, Nikiforova MN, et al. Cytomorphological and molecular genetic findings in pediatric thyroid fine-needle aspiration. Cancer Cytopathol. 2012;120(5):342-50.

Scholz S, Smith JR, Chaignaud B, Shamberger RC, Huang SA. Thyroid surgery at Children’s Hospital Boston: A 35-year single-institution experience. J Pediatr Surg. 2011;46(3):437-42.