DOI: http://dx.doi.org/10.18203/2349-3291.ijcp20193152

Clinical and laboratory evaluation of lymphadenopathy in particular with fine needle aspiration cytology

Nageshwara Rao K., Harisha Gopal, Gautham M.

Abstract


Background: To know the various causes of lymphadenopathy in children and to know the usefulness of FNAC in diagnosis of various causes of lymphadenopathy.

Methods: Children less than 12 years with significant lymphadenopathy (lymphadenopathy of >1 cm in cervical, axillary and >1.5 cm in inguinal region) were included.

Results: A total of 50 children were enrolled in the study. The incidence of lymphadenopathy was more common in the age group of 4-8 year during the lymphoid phase with male preponderance of all the causes infections especially tuberculosis was the major cause of lymphadenopathy which is totally preventable by giving BCG vaccination. The sensitivity of FNAC in the present study was 71.3%. In 3 cases FNAC 69 was not done because peripheral smear examination revealed that the patients are suffering from acute lymphoblastic leukemia.

Conclusions: FNAC is a simple bed side investigation though traumatic is of immense value for diagnosing various cases. Even though it may not be a replacement for lymphnode biopsy, it is preferred as a first line investigation because of its simple procedure.


Keywords


Children, Fine needle aspiration cytology, Infections, Lymphadenopathy, Lympnode, Tuberculosis

Full Text:

PDF

References


Oski FA, Lake MA. Peripheral lymphadenopathy in Childhood. Am J Dis Child. 1978;132(4):357-9.

Bedros AA, Mann JP. Lymphadenopathy in Children. Acta Paed. 1982;3101(28):341-77.

Grossman M, Shiramizu B. Evaluation of lymphadenopathy in children. Curr Opin Paediatr. 1994;6(1):68-76.

Udani PM. Tuberculosis in Children. Ind J Pediatr. 1994;61:451-62.

Rock A, Cammitta B. Lymphadenopathy. In Waldo Nelson, Behraman RE, Kliegman, Ed. Textbook of Pediatrics;15th Ed. Philadelphia:WB Saunders, 2996;1996:1441.

Friedmann AM. Evaluation and Management of Lymphadenopathy in Children Pediatr Rev. 2008;29(2);53-60.

Reddy MP, Moorchung N, Chaudhary A. Clinico-pathological profile of pediatric lymphadenopathy. Indian J Pediatr. 2002;69(12):1047-51.

Sivaprasath P, Venkatadesikalu M, Dhanalakshmi M. Diagnostic accuracy of fine needle aspiration cytology of significant cervical lymphadenopathy in pediatric age group (1-12 years). Int J Curr Med Sci. 2016;.6(6)107-11.

Singh N, Singh A, Chauhan R. Fine needle Aspiration Cytology in evaluation of Lymphadenopathy in Pediatric Age Group: Our Experience at Tertiary Care Centre. Int J Cotempr Med Res. 2016;3(5):1347-51.

Ceyda Karadeinz and Aynur Oguz. The etiology of periferal lymphadenopathy in children. Pediatr Hematol Oncol. 1999;16(6):525-31.

Singh N, Singh A, Chauhan R. Fine needle Aspiration Cytology in evaluation of Lymphadenopathy in Pediatric Age Group: Our Experience at Tertiary Care Centre. Int J Cotempr Med Res. 2016;3(5):1347-51.

Bezabih M, Mariam DW, Selassie SG. Fine needle aspiration cytology of suspected tuberculous lymphadenitis. Cytopathology. 2002;13(5):284-90.

Mitra S, Ray S, Mitra PK. Fine needle aspiration cytology of supraclavicular lymph nodes: Our experience over a three-year period. J Cytol. 2011;28(3):108-10.

Yaris N, Cakir M, Sözen E, Cobanoglu U. Analysis of children with peripheral lymphadenopathy. Clin Pediatr (Phila). 2006;45(6):544-9.

Mohan MS, Siddique AM, Somaiah G, Prasad AS, Prasad SG. Cervical Lymphadenopathy and Its Clinico Pathological Profile in Children. Sch J App Med Sci. 2014;2(1B):216-20.

Knight PJ, Mulne AF, Vassy LE. When is lymph node biopsy indicated in children with enlarged peripheral nodes?. Pediatrics. 1982;69(4):142-8.

Ojala KS, Rakangas P. Compression of pre and post-operative bacteriology of chronic ears. J Larngol Otol. 1981;95(10):1023-9.

Imad AEH, Lawrence CC, Fahad AAR, and Sharanamma MK. Fine Needle Aspiration Cytology of Head and Neck Masses Seven Years’ Experience in a Secondary Care Hospital. Acta Cytologica. 2003;47(3):14-9.

Ramzy I, Rone R, Shulternover SJ, Buhaug J. Lymph node aspiration biopsy. Diagnostic reliability and limitations; an analysis of 350 cases. Diagn Cytopatho.1985;1(1):39-45.

Stansfield AJ, Ardenne D. Lymph node biopsy interpretation. 2nd Ed. Edinburgh: Churchill Livingstone, Chapter 13 In: lymph node lab interpretation;1992:223-230.

Buchino JJ, Jones VF. Fine needle aspiration in the evaluation of children with 79 y mphadenopathy. Arch Pediatr Adolesc Med. 1994;148(12):1327-30.

Singh UR, Bhatia A, Gadre DV, Talwar V. Cytological diagnosis of TB lymphadenitis in children by FNAC. Indian J Pediatr. 1992;59(1):115-8.

Annam V, Kulkarni MH, Puranik RB. Clinicopathologic profile of significant cervical lymphadenopathy in children aged 1-12 years. Acta Cytol. 2009;53(2):174-8.