Sero-prevalence of vitamin D deficiency among pediatric subjects visiting central railway hospital, Byculla, Mumbai, India: a cross sectional study

Ajay B. Kale, Mohd Haseeb, Dipti Jain, Bharat Jain, Apurva Deshmukh


Background: Vitamin D deficiency leads to improper bone mineralization and causes rickets in children. Recently role of vitamin D has been found in a wide range of physiological functions, including cell differentiation, immune function and insulin production.

Methods: This study was hospital-based cross-sectional study. Participants were recruited from population of young children aged 6 months to 15 years attending Dr. Babasaheb Ambedkar central railway hospital at Byculla, Mumbai, India. Sample size was 150 subjects. Study duration was May 2012 to May 2013. Vitamin D levels were measured by electrochemiluminescent immunoassay. Vitamin D deficiency was defined as levels <50 nmol/L.

Results: 127 children (84.6%) were vitamin D deficient. 91 subjects were males and 59 were females. 78 (85%) males and 49 (83%) females had vitamin D deficiency. The difference was not statistically significant (p=0.658). The prevalence of vitamin D deficiency in age group 6 months to 5 years was 87.5%, 6 to10 years was 84.9% and 11-15 years was 81.6%. The difference was not statistically significant (p=0.734).

Conclusions: There was very high prevalence of vitamin D deficiency in study population. We found no age and gender variation in vitamin D deficiency.


Hypovitaminosis D, Sun exposure, Paediatric population

Full Text:



Geeta T, Chugh R. Poor Vitamin D Status in Healthy Populations in India: A Review of Current Evidence. Int J Vitam Nutr. Res. 2015;85(3-4):185 -201.

Hollick MF. Vitamin D: A D-lightful solution for health. J Investig Med. 2011;59:872-80.

Beloyartseva M, Mithal A, Kaur P, Kalra S, Baruah MP, Mukhopadhyay S. Widespread vitamin D deficiency among Indian health care professionals. Arch Osteoporos. 2012;7:187-92.

Pettifor JM. Vitamin D and/or calcium deficiency rickets in infants and children: a concern for developing countries? Indian Pediatrics. 2007;44:893-5.

Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP. Endocrine Society. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(7):1911-30.

Tiwari L, Puliyel JM. Vitamin D level in slum children of Delhi. Indian Pediatrics. 2004;41:1076-77.

Marwaha RK, Tandon N, Reddy DR, Aggarwal R, Singh R, Sawhney RC et al. Vitamin D and bone mineral density status of healthy school children in northern India. Am J Clin Nutr. 2005;82(2):477-82.

Basu S, Gupta R, Mitra M, Ghosh A. Prevalence of vitamin d deficiency in a pediatric hospital of eastern India. Indian J Clin Biochem. 2015;30(2):167-73.