Role of maternal Anemia on cord hemoglobin and infant hemoglobin and ferritin level at nine months of age


  • Abu Sadique Department of Obstetrics and Gynecology, North Bengal Medical College, Sushrutnagar, Darjeeling, India
  • Achinta K. R. Mallick Department of Pediatrics, Military Hospital Kirkee, Pune, Maharashtra, India



Anaemia, Cord blood haemoglobin, Infancy, Pregnancy


Background: Primary objective was to compare hemoglobin at 9 months and secondary objective was to compare birth weight, cord hemoglobin and serum ferritin at 9 months between infants born to anaemic and non anaemic mothers.

Methods: In this prospective cohort study, we compared cord hemoglobin, birth weight, hemoglobin at 09 months & serum ferritin at 09 months in infants of anaemic and non anaemic mothers.  Subject of the study was all inborn term infants (n = 344).

Results: Cord blood hemoglobin was similar between infants born to anaemic and non anaemic mothers. However, infants born to anaemic mothers weighed less at birth and had lower hemoglobin at 9 months of age.

Conclusions: Infants born to anaemic mothers are at higher risk of developing anaemia in late infancy which may remain undetected at birth.


World Health Organization. The global prevalence of anaemia in 2011: Available at: Accessed 06 June 2019.

Garn SM, Ridella SA, Petzold AS, Falkner F. Maternal hematologic levels and pregnancy outcomes. Semin Perinatol. 1981;5(2):155-62.

Murphy JF, Newcombe RG, O'riordan J, Coles EC, Pearson JF. Relation of haemoglobin levels in first and second trimesters to outcome of pregnancy. The Lancet. 1986;327(8488):992-5.

Eneroth H, Persson LÅ, El Arifeen S, Ekström EC. Infant anaemia is associated with infection, low birthweight and iron deficiency in rural Bangladesh. Acta Paediatr. 2011;100(2):220-5.

Lubach GR, Coe CL. Preconception maternal iron status is a risk factor for iron deficiency in infant rhesus monkeys (Macaca mulatta). The J Nutri. 2006;136(9):2345-9.

Scholl TO. Maternal iron status: relation to fetal growth, length of gestation, and iron endowment of the neonate. Nutrition Reviews. 2011;69(suppl_1):S23-9.

Kilbride J, Baker TG, Parapia LA, Khoury SA, Shuqaidef SW, Jerwood D. Anaemia during pregnancy as a risk factor for iron-deficiency anaemia in infancy: a case-control study in Jordan. International J Epidemiol. 1999;28(3):461-8.

Erdem A, Erdem M, Arslan M, Yazici G, Eskandari R, Himmetoglu Ö. The effect of maternal anemia and iron deficiency on fetal erythropoiesis: comparison between serum erythropoietin, hemoglobin and ferritin levels in mothers and newborns. J Maternal-Fetal Neonatal Med. 2002;11(5):329-32.

Dalal E, Shah J. A comparative study on outcome of neonates born to anemic mothers versus non anemic mothers. Natl J Med Res. 2014;4(4):270-3.

Ronnenberg AG, Wood RJ, Wang X, Xing H, Chen C, Chen D, Guang W, Huang A, Wang L, Xu X. Preconception hemoglobin and ferritin concentrations are associated with pregnancy outcome in a prospective cohort of Chinese women. The J Nutri. 2004;134(10):2586-91.

Zhang Y, Jin L, Liu JM, Ye R, Ren A. Maternal hemoglobin concentration during gestation and risk of anemia in infancy: secondary analysis of a randomized controlled trial. The J Pediatr. 2016;175:106-10.

Kumar A, Rai AK, Basu S, Dash D, Singh JS. Cord blood and breast milk iron status in maternal anemia. Pediatr. 2008;121(3):e673-7.

Faridi MM, Singh O, Rusia U. Mother's iron status, breastmilk iron and lactoferrin–are they related?. Euro J Clinic Nutri. 2006;60(7):903.






Original Research Articles