DOI: http://dx.doi.org/10.18203/2349-3291.ijcp20192173

Serum zinc levels in children with simple febrile seizures

Malavika P. Santappanawar, Habeeb U. Khan, Jaidev M. Devdas, Sujonitha John, Pavan Hegde

Abstract


Background: Febrile seizures are the most common seizures in childhood and are often associated with nutritional deficiencies. The present study was done to find any correlation of serum zinc levels in children with simple febrile seizures.

Methods: This study was a hospital based prospective case control study, involving 60 children (30 cases and 30 controls) aged between 6 months to 60 months. Serum zinc level was measured in all subjects by atomic absorption spectrophotometer. Data was analysed by using frequency, percentage and Pearson’s chi square test..

Results: Most cases (80%) had serum zinc levels <90 mcg/dl, in comparison with children in the control group where only 30% had serum zinc levels <90 mcg/dl. The mean serum zinc level was 78.9±14.26 mcg/dl in cases with simple febrile seizures and 96.7±12.12 mcg/dl in the control group.

Conclusions: The mean serum zinc level was significantly lower in children with simple febrile seizures in comparison with controls.


Keywords


Children, Febrile, Seizures, Zinc

Full Text:

PDF

References


Guidelines for Epidemiologic Studies on Epilepsy. Commission on Epidemiology and Prognosis, International League Against Epilepsy. Epilepsia. 1993; 34(4):592-6.

Mohamad A. Mikati and Abeer J. Hani. Seizures in childhood. Nelson Textbook of paediatrics. 20th ed. Philadelphia: Elsvier. Chapter 593; 2015:2829.

Gayathri D, Balachandar CS, Chidambaranathan S and Nisha. Serum Zinc Levels In Children With Simple Febrile Seizures. Int J Current Med Sci. 2015;9(5):28-34.

Karthikeyan P, Prasanna R, Sathyamoorthy M, Reddy SM, Sekar P. Serum zinc levels in children with simple febrile seizures. Int J Contemp Pediatr. 2015;2(4):424-7.

Mohammad Reza Salehiomran and Masoumeh Mahzari. Zinc Status in Febrile Seizure: A Case-Control Study. Iran J Child Neurol. 2013 Autumn;7(4):20-3.

Heydarian F. Serum Zinc level in patients with simple febrile seizure. Iran J Child Neurol. 2010 Oct 6;4(2):41-4.

Ganesh R, Janakiraman L. Serum Zinc Levels in Children with Simple Febrile Seizure. Clin Pediatr 2008;47(2):164-6.

Mahyar A, Pahlavan A, Varaseth Nejah A. Serum Zinc level in children with febrile seizures. Acta Medica Iranica. 2008;46(6):477-80.

Ganesh R, Janakiraman L and Meenakshi B. Serum zinc levels are low in children with simple febrile seizures compared with those in children with epileptic seizures and controls. Ann Trop Paediatr. 2011;31(4):345-9.

Jun-Hwa Lee, Jeong Hyun Kim. Comparison of Serum Zinc Levels Measured by Inductively Coupled Plasma Mass Spectrometry in Preschool Children with Febrile and Afebrile Seizures. Ann Lab Med. 2012;32(3):190-3.

Ehsanipour F, Talebi-Taher M, Harandi N, Kani k. Serum zinc level in children with febrile convulsion and its comparison with that of control group. Iranian J Pediatr. 2009;19(1):65-8.

Sampathkumar P, Kannan KS. A comparative study of serum zinc levels in children with febrile seizures and children with fever without seizures in an urban referral hospital. Int J Contemp Pediatr. 2018 May;5(3):977-82.

Cho WJ, Son BH, Kim SW. Levels of Sodium and Zinc concentration in febrile convulsion. Korean Child Neural Soc. 1999;7(2):214-9.

Papierkowski A, Mroczkowska-Juchkiewicz A, Pawłowska-Kamieniak A, Pasternak K. Magnesium and zinc levels in blood serum and cerebrospinal fluid in children with febrile convulsions. Pol Merkur Lekarski. 1999 Mar;6(33):138-40.

Mollah MA, Rakshit SC, Anwar KS, Arslan MI, Saha N, Ahmed S, et al. Zinc concentration in serum and cerebrospinal fluid simultaneously decrease in children with febrile seizure: Findings from a prospective study in Bangladesh. Acta Paediatr. 2008;97(12):1707‐11.

Gunduz Z, Yavuz I, Koparal, et al. Serum and CSF zinc levels in children with febrile convulsions. Acta Paediatr JPN. 1996;38(3):237-41.

Garty BZ, Olomucki R, Lerman-sagie T, et al. CSF zinc concentrations in febrile convulsions. T Arch Dis child. 1995;73(4):338-41.

Hartfield DS, Tan J, Yager JY, Rosychuk RJ, Spady D, Haines C, et al. The association between iron deficiency and febrile seizures in childhood. Clinical Pediatrics. 2009;48(4):420-6.

Bhat JA, Kurmi R, Ara R, Kumar S. Level of Micronutrient [zinc] and its Association with Seizures in Children: A Case Control Study. Acad J Ped Neonatol. 2018;7(2):555765.

Ahmad Talebian, Zarichehr Vakili, Safar Ali Talar. Assessment of the Relation between Serum Zinc & Magnesium Levels in Children with Febrile Convulsion. Iranian J Pathol. 2009;4(4):157-60.

Margaretha L, Masloman N. Correlation between serum zinc level and simple febrile seizure in children. Paediatr Indones. 2010;50:326-30.