Study of common aeroallergens in children with wheeze: a hospital based cross sectional study


  • Kalavathy Jasmine Masillamoni Department of Pediatrics, Shadan Institute of Medical Sciences, Peerancheru, Hyderabad, Telangana, India
  • Nayantara R. Gandra Department of Pediatrics, Ayaan Institute of Medical Sciences and Teaching Hospital, Moinabad, Hyderabad, Telangana, India



Common allergens, Prevention, Recurrent wheezing, Treatment, vaccine


Background: Prevention of diseases of the allergic origin depends upon the early identification of aeroallergens. Vaccine for allergy may not be required in all cases. but when treatment is not successful, then there is requirement of the vaccine. Objective of study allergens responsible for inducing recurrent wheezing

Methods: A cross sectional observation study was carried out at Departmetn of Pediatric, Shadan Institue of Medical Sciences, Peerancheru, Hyderabad, Telangana, India from June 2017 to June 2018 among 100 children with recurrent (4 or more episodes of wheezing in past one year) ages between 2 yrs to 10 yrs. Using the guidelines for skin prick test as per the European committee, the skin prick test was carried out. Insulin syringe was used for the intradermal test. It is done using standardized allergen extracts (Creative Diagnostic Medicare pvt ltd) were done for our cases.

Results: Out of 100 children studied, 67 children were found to be sensitive to at least one of the aeroallergen and 33 children were found to be negative for all the aeroallergens. A statistically significant correlation is seen between the age groups and sensitivity (p value 0.025). Out of 67 children with a positive skin prick test, 66 children showed the sensitivity to indoor allergens. The association between the indoor allergens and the wheezing is statistically significant (P value <0.0001)

Conclusion: In children the sensitivity to indoor allergens is more prevalent than sensitivity to outdoor allergens. Sensitivity to pollen was found in older children more than 5 years of age.


Worldwide variations in the prevalence of Bronchial Asthma symptoms: International study of Bronchial Asthma and allergies in childhood (ISAAC). Eur Respir J 1998;12:315-35. Available at: Accessed 28 June 2017.

Reid J, Marciniuk DD, Cockcroft DW. Bronchial Asthma management in the emergency department. Can Respir J. 2000;7(3):255-60.

Gürkan F, Ece A, Haspolat K, Derman O, Bosnak M. Predictors for multiple hospital admissions in children with Bronchial Asthma. Can Respir J. 2000;7(2):163-6.

Veerapaneni V, Jayaraj BS, Lokesh KS, Chaya SK, rao Veerapaneni V, Holla A, et al. Prevalence of Allergic Rhinitis, Atopic Dermatitis and Asthma among school children in Hyderabad, India. J Allergy and Clin Immunol. 2017;139(2):205.

Paramesh H. Epidemiology of Bronchial Asthma in India. Indian J Pediatr. 2002;69(4):309-12.

Singh AB, Kumar P. Aeroallergens in clinical practice of allergy in India. Anoverview. Ann Agric Environ Med. 10:131-6.

Fereidouni M, Farid Hossini R, Jabbari Azad F Assarehzadegan MA, Varasteh A. Skin prick test reactivity to common aeroallergens among allergic rhinitis patients in Iran. Allergol Immunopathol. 2009;37(2):73-9.

Behmanesh F, Shoja M, Khajedaluee M. Prevalence of aeroallergens in childhood asthma in Mashhad. Maced J Med Sci. 2010;3(3):295-8.

Farhoudi A, Razavi A, Chavoshzadeh Z, Heidarzadeh M, Bemanian MH, Nabavi M. Descriptive Study of 226 Patients with Allergic Rhinitis and Asthma. Iran J Allergy, Asthma Immunol. 2005;4(2):99-101.

Dave L, Srivastava N. A Study of Sensitisation Pattern to Various Aero-Allergens by Skin Prick Test in Patients of United Airway Disease (UAD) in Bhopal, Madhya Pradesh, India. Research Journal of Pharmaceutical, Biological and Chemical Sciences. 2014;5(4):1397-1403.

Mohammadi K, Gharagozlou M, Movahedi M. A Single Center Study of Clinical and Paraclinical Aspects in Iranian Patients with Allergic Rhinitis. Iran J Allergy Asthma Immunol. 2008;7:163-7.

Sporik R, Holgate ST, Platts-Mills TA, Cogswell JJ. Exposure to house-dust mite allergen (Der p ) and the development of asthma in childhood. A prospective study. N Engl J Med. 1990;323(8):502-7.

Khazaei HA, Hashemi SR, Aghamohammadi. The study of type 1 allergy prevalence among people of South-East of iran by skin prick test using common allergens. Iran J Allergy Asthma Immunol. 2003;2(3):165-8.

Liam CK, Loo KL, Wong CM, Lim KH, Lee TC. Skin prick test reactivity to common aeroallergens in asthmatic patients with and without rhinitis. Respirol. 2002; 7(4):345-50.

Chew FT, Lim SH, Goh DY, Lee BW. Sensitization to local dust-mite fauna in Singapore. Allergy. 1999;54(11)1150-9.

Prasad R, Verma S, Dua R, Kant S, Kushwaha RA, Agarwal SP. A study of skin sensitivity to various allergens by skin prick test in patients of nasobronchial allergy. Lung India. 2009;26:70-3.

Agrawal RL, Chandra A, Sachin J. Identification of common allergens by skin prick test associated with united airway disease in Allahabad, Uttar Pradesh, India. Indian J Allergy Asthma Immunol. 2008; 22(1):7-13.

Farhoudi A, Pourpak M, Mesdaghi Z, Chavoshzadeh Z, Kazemnejad AN. The study of cockroach allergy in Iranian children with asthma. Iran J Med Sci. 2002;27(4):156-60.

Pendino P, Agüero C, Cavagnero P. Lopez K, Kriunis I, Molinas J. Aeroallergen sensitization in wheezing children from rosario, Argentina. World Allergy Organ J. 2011;4(10):159-63.

Sheehan WJ, Rangsithienchai PA, Baxi SN, Gardynski A, Bharmanee A, Israel E, et al. Age-specific prevalence of outdoor and indoor aeroallergen sensitization in Boston. Clin Pediatr (Phila). 2010;49(6):579-85.






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