Ketogenic diet: a promising alternative nonpharmacology treatment for pediatric epilepsy


  • Bella Kurnia Faculty of Medicine, Kristen Krida Wacana University, Jakarta, Indonesia



Ketogenic diet, Nonpharmacology, Pediatric epilepsy, Pediatric, Seizure


Epilepsy is a syndrome of brain dysfunction induced by the aberrant excitability of certain neurons. Despite advances in surgical technique and anti-epileptic drug in recent years, recurrent epileptic seizures remain intractable and lead to a serious morbidity in the world. The ketogenic diet (KD) is a nonpharmacologic treatment that has been used for refractory epilepsy since 1921. The KD is a high-fat, low-carbohydrate, and restricted protein diet, which is calculated and weighed for each individual patient. The goal of the KD treatment is to bring the brain into a state of ketosis to control seizures. Many studies have shown that ketogenic diet was very useful in controlling refractory epilepsy.


Kania BAZ, Spellman E. An overview of the ketogenic diet for pediatric epilepsy. Nutrition in Clin Prac. 2008;23(6):589-95.

Liu G, Slater N, Perkins A. Epilepsy: treatment options. Am Acad Fam Physician. 2017;96(2):87,90-5.

Saad K. Childhood epilepsy: an update on diagnosis and management. Am J Neurosci. 2014;5(2):36-9.

Jan MM. Clinical review of pediatric epilepsy. Saudi Arabia: Neurosci. 2005;10(4):255-64.

Flynn S, Babi MA. Anticonvulsants. Pharmacol Therap Dentistry. 2017;12(1):176-92.

Kumar S, Singh G. Pathophysiology of epilepsy: an updated review. Int J Med Heal Res. 2016;2:32-6.

Expert committee on pediatric epilepsy. Guidelines for diagnosis and management of childhood epilepsy. Ind Acad Pediatrics. 2007(1);46:685-93.

Bough KJ, Rho JM. Anticonvulsant mechanisms of the ketogenic diet. Epilepsia. 2007;48(1):43-58.

Runyon AM, So TY. The use of ketogenic diet in pediatric patients with epilepsy. ISRN Ped. 2012;1:1-10.

Sampaio LPDB, Takakura C, Manreza MLG. The use of a formula-based ketogenic diet in children with refractory epilepsy. Brasil: Sci Elo. 2017;75(4):234-37.

Neal EG, Chaffe H, Schwartz RH. The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial. Lancet Neurol. 2008;7(1):500-06.

Lambrechts DAJE, Kinderen RJA, Vles JSH, Aja DL, Aldenkamp AP, Majoie HJM. A randomized controlled trial of the ketogenic diet in refractory childhood epilepsy. John Wiley Sons Ltd. 2016; 1:1-9.

Vamecq J, Vallee L, Lesage F, Gressens P, Stables JP. Antiepileptic popular ketogenic diet: emerging twists in an ancient story. Elsevier Progress Neurobiol. 2005;75:1-28.

Spilioti M, Pavlou E, Gogou M, Katsanika I, Alataki PE, Grafakou O, et al. Valproate effect on ketosis in children under ketogenic diet. Euro J Paediatr Neurol. 2016;20(4):555-9.

Zhang Y, Xu J, Zhang K, Yang W, Li B. The anticonvulsant effects of ketogenic diet on epileptic seizures and potential mechanisms. Current Neuropharmacol. 2018;16(1):66-70.






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