A case of diabetic fetopathy: caudal regression syndrome and associated anomalies


  • Somnath Pal Department of Neonatology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India
  • Syamal Kumar Sardar Department of Neonatology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India




Caudal regression syndrome, Diabetes, Fetopathy, Lumbosacral agenesis


Uncontrolled periconceptional diabetes in mother  can give rise to severe malformation in the offspring. Author describe a case of  diabetic fetopathy  presenting as a case of  Caudal regression syndrome along with cardiovascular, gastrointestinal and genitourinary anomaly. Though most cases of Caudal regression syndrome are sporadic, it is the most specific lesion of diabetic fetopathy. Clinical presentation varies depending on the severity of the neurological lesion along with the presence of other anomalies, most commonly genitourinary malformation. The index case described here had a type IV lumbosacral agenesis with severe bilateral motor and sensory deficits along with D-Transposition of great arteries and Pyloric atresia. Such cases arise due to inadequate prenatal care of diabetic mother, which is not uncommon in developing country like India.


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