Acute kidney injury in a critically ill influenza: a H1N1 infected child

Dinesh Kumar Jayapalan; Sangeetha Geminiganesan; Shruthi Parthasarathy; Niranjana Varadharaju; Nithya Bhaskar

doi:10.18203/2349-3291.ijcp20192791

Authors

Dinesh Kumar Jayapalan Department of Pediatrics, Sri Ramachandra Hospital, Porur, Chennai, Tamil Nadu, India
Sangeetha Geminiganesan Department of Pediatrics, Sri Ramachandra Hospital, Porur, Chennai, Tamil Nadu, India
Shruthi Parthasarathy Department of Pediatrics, Sri Ramachandra Hospital, Porur, Chennai, Tamil Nadu, India
Niranjana Varadharaju Department of Pediatrics, Sri Ramachandra Hospital, Porur, Chennai, Tamil Nadu, India
Nithya Bhaskar Department of Pediatrics, Sri Ramachandra Hospital, Porur, Chennai, Tamil Nadu, India

DOI:

https://doi.org/10.18203/2349-3291.ijcp20192791

Keywords:

Acute Renal failure in H1N1 infection, Complication of H1N1 infection, H1N1 in children

Abstract

Influenza H1N1 infection is a globally recognized epidemic and is known for several extra-pulmonary complications. Here, for the first time we report a case of a six-year old male child with severe H1N1 infection with acute kidney injury. The child was referred to our center with fever, chills, cough and cold for 2 days. Investigations revealed H1N1 infection with deranged LFT and RFT with anuria. Child was subjected to mechanical ventilation and received higher antibiotics in addition to oseltamivir. The child underwent 13 cycles of hemodialysis and renal profile normalized after a period of 35 days. Our case highlights the importance of recognizing extra-pulmonary complications of H1N1 infection in the pediatric population and the preparation required by healthcare practitioners to reduce the associated mortality.

Metrics

Metrics Loading ...

References

Seasonal Influenza (H1N1)– State/UT- wise, Year- wise number of cases and death from 2010 to 2017 Delhi: National Center for Disease Control. Available from: https://ncdc.gov.in/showfile.php?lid=275.

Seasonal Influenza (H1N1)– State/UT - wise, Year-wise number of cases and deaths from 2011-2018 Delhi: National Center for Disease Control. Available from: https://ncdc.gov.in/showfile.php?lid=280.

Sellers SA, Hagan RS, Hayden FG, Fischer WA, 2nd. The hidden burden of influenza: A review of the extra-pulmonary complications of influenza infection. Influenza and other respiratory viruses. 2017;11(5):372-93.

Bagshaw SM, Sood MM, Long J, Fowler RA, Adhikari NK, Canadian Critical Care Trials Group HNC. Acute kidney injury among critically ill patients with pandemic H1N1 influenza A in Canada: cohort study. BMC nephrology. 2013;14:123.

Demirjian SG, Raina R, Bhimraj A, Navaneethan SD, Gordon SM, Schreiber MJ, Jr., et al. 2009 influenza A infection and acute kidney injury: incidence, risk factors, and complications. American journal of nephrology. 2011;34(1):1-8.

Jung JY, Park BH, Hong SB, Koh Y, Suh GY, Jeon K, et al. Acute kidney injury in critically ill patients with pandemic influenza A pneumonia 2009 in Korea: a multicenter study. Journal of critical care. 2011;26(6):577-85.

Martin-Loeches I, Papiol E, Rodriguez A, Diaz E, Zaragoza R, Granada RM, et al. Acute kidney injury in critical ill patients affected by influenza A (H1N1) virus infection. Critical care. 2011;15(1):R66.

Nin N, Lorente JA, Soto L, Rios F, Hurtado J, Arancibia F, et al. Acute kidney injury in critically ill patients with 2009 influenza A (H1N1) viral pneumonia: an observational study. Intensive care medicine. 2011;37(5):768-74.

Pettila V, Webb SA, Bailey M, Howe B, Seppelt IM, Bellomo R. Acute kidney injury in patients with influenza A (H1N1) 2009. Intensive care medicine. 2011;37(5):763-7.

Tignanelli CJ, Wiktor AJ, Vatsaas CJ, Sachdev G, Heung M, Park PK, et al. Outcomes of Acute Kidney Injury in Patients With Severe ARDS Due to Influenza A(H1N1) pdm09 Virus. American journal of critical care : an official publication, American Association of Critical-Care Nurses. 2018;27(1):67-73.

Sood MM, Rigatto C, Zarychanski R, Komenda P, Sood AR, Bueti J, et al. Acute kidney injury in critically ill patients infected with 2009 pandemic influenza A(H1N1): report from a Canadian Province. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2010;55(5):848-55.

Abe M, Higuchi T, Okada K, Kaizu K, Matsumoto K. Clinical study of influenza-associated rhabdomyolysis with acute renal failure. Clinical nephrology. 2006;66(3):166-70.

Ayala E, Kagawa FT, Wehner JH, Tam J, Upadhyay D. Rhabdomyolysis associated with 2009 influenza A(H1N1). Jama. 2009;302(17):1863-4.

Fearnley RA, Lines SW, Lewington AJ, Bodenham AR. Influenza A-induced rhabdomyolysis and acute kidney injury complicated by posterior reversible encephalopathy syndrome. Anaesthesia. 2011;66(8):738-42.

Bosch X, Poch E, Grau JM. Rhabdomyolysis and acute kidney injury. The New England journal of medicine. 2009;361(1):62-72.