Clinico-epidemiological spectrum of early onset neonatal sepsis in neonates admitted in NICU of a tertiary care institute

Ashwani Kumar; Gursharan Singh Narang; Gurmeet Singh; Navneet Virk; Ashiana Singh

doi:10.18203/2349-3291.ijcp20191071

Authors

Ashwani Kumar Department of Pediatrics, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab, India
Gursharan Singh Narang Department of Pediatrics, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab, India
Gurmeet Singh Department of Pediatrics, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab, India
Navneet Virk Department of Pediatrics, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab, India
Ashiana Singh Department of Pediatrics, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab, India

DOI:

https://doi.org/10.18203/2349-3291.ijcp20191071

Keywords:

Blood culture, Early onset sepsis, Sensitivity, Term neonates

Abstract

Background: Neonatal sepsis is a clinical syndrome characterized by signs and symptoms of infection with or without accompanying bacteremia in the first month of life. Neonatal sepsis may be classified into two groups : early onset sepsis and late onset sepsis . Early onset neonatal sepsis is generally associated with the acquisition of microorganisms from the mother and usually presents with respiratory distress and pneumonia.

Methods: The study included one hundred term neonates with early onset neonatal sepsis. A septic screen including total leukocyte count, absolute neutrophil count, blood smear evaluation, blood cultures and C-reactive protein (CRP) were performed in all neonates with suspected sepsis to corroborate early onset sepsis diagnosis. Epidemiological parameters including gender of the neonate, mode of delivery, rural/urban residence were recorded in addition to clinical profile.

Results: Respiratory distress was the most common presentation in the form of tachypnea, seen in 63 (63.0%) neonates. In present study, Staphylococcus aureus was the most common organism isolated followed by Staphylococcus epidermidis, Staphylococcus hominis, Acinetobacter baumannii and Klebsiella pneumonae.

Conclusions: Early onset neonatal sepsis was seen more in males. Among the gram-positive Staphylococcus aureus and among gram negative Acinetobacter baumannii and Klebsiella pneumonae were most common organisms to be isolated.

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