DOI: http://dx.doi.org/10.18203/2349-3291.ijcp20191043

Prevalence of vitamin D deficiency in children with lower respiratory tract infection

Chandrashekhara ., Srinivasu Pampana

Abstract


Background: Vitamin D has a role in lung growth, preserving lung function, and preventing pulmonary infection.

Methods: Hospital based cross sectional prospective study was done for a period of one year from January 2017 to December 2017, at the AJ Institute of Medical Sciences, Mangalore. A total of 69 patients were admitted with LRTI during the duration of 1 year, which includes pneumonia and bronchiolitis. Out of 69 patients admitted with LRTI, 10 were excluded from the study as they were not fulfilled the criteria.

Results: A total 59 children were enrolled in the study with LRTI, out of which 50 (84.7%) were vitamin D deficiency 6 (10.1%) were insufficiency and only 3 (5.08%) had normal vitamin D values, which was statistically highly significant with p value <0.05. Vitamin D deficiency is more common in less than 1 year and also in male child. Vitamin D deficiency is also common among preterm babies who were not on Vitamin D supplements, exclusively breast fed babies and among lower socio economic status especially in class 4. Authors found that 13 (22.03%) members were having a history of previous LRTI out of which 11 (84.6%), 2 (15.3%) had Vitamin D deficiency and insufficiency respectively. Among study group, 16 (27.11%) were diagnosed to have bronchiolitis, out of which 10 (62.5%), 4 (25%), 2 (12.5%) patients were found to have Vitamin D deficiency, insufficiency and normal values respectively. Children who diagnosed as pneumonia were 43 (72.88%), out of them 40 (93%), 2 (4.6%), 1 (2.3%) were having deficiency, insufficiency and normal values of Vitamin D respectively.

Conclusions: Vitamin D deficiency is common in children with LRTI especially among exclusively breastfed, born preterm and children from lower socio economic status. Early recognition and treatment of Vitamin D deficiency can prevent morbidity associated with rickets and possibly frequent LRTI.


Keywords


Children, Lower respiratory tract infections, Prevalence, Vitamin D deficiency

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References


Gupta A. Vitamin D deficiency in India: prevalence, causalities and interventions. Nutr. 2014;6(2):729-75.

Holick MF. Vitamin D: A millenium perspective. J Cell Biochem. 2003;88:296-307.

Holick MF. Vitamin D and health: evolution, biologic functions, and recommended dietary intakes for vitamin D. In Vitamin D. Humana Press; 2010:3-33.

Zosky GR, Berry LJ, Elliot JG, James AL, Gorman S, Hart PH. Vitamin D deficiency causes deficits in lung function and alters lung structure. Am J Respir Crit Care Med. 2011;183:1336-43.

Black PN, Scragg R. Relationship between serum 25-hydroxyvitamin D and pulmonary function in the third national health and nutrition examination survey. Chest. 2005;128:3792-8.

McNally JD, Leis K, Matheson LA, Karuananyake C, Sankaran K, Rosenberg AM. Vitamin D deficiency in young children with severe acute lower respiratory infection. Pediatr Pulmonol. 2009;44:981-8.

Van Schoor NM, Lips P. Worldwide Vitamin D status. Best Pract Res Clin Endocrinol Metab. 2011;25:671-80.

Mithal A, Wahl DA, Bonjour JP, Burckhardt P, Dawson-Hughes B, Eisman JA, et al. Global Vitamin D status and determinants of hypovitaminosis D. Osteoporos Int. 2009;20:1807-20.

Mulholland K. Global burden of acute respiratory infections in children: implications for interventions. Pediatr Pulmonol. 2003;36:469-74.

Rudan I, Boschi-Pinto C, Biloglav Z, Mulholland K, Campbell H. Epidemiology and etiology of childhood pneumonia. Bull World Health Organ 2008;86:408-16.

Cannell JJ, Vieth R, Umhau JC, Holick MF, Grant WB, Madronich S, et al. Epidemic influenza and vitamin D. Epidemiol Infect. 2006;134:1129-40.

Wayse V, Yousafzai A, Mogale K. Association of subclinical vitamin D deficiency with severe acute lower respiratory infection in Indian children under 5y. Eur J Clin Nutr. 2004;58:563-7.

Rubinacci A, Moro GE, Boehm G, Terlizzi FD, Moro GL, Cadossi R. Quantitative ultrasound for the assessment of osteopenia in preterm infants. Eur J Endocrinol. 2003;149:307-15.

Guo LY, Li W, Cheng XF, Li HR, Sun CR, Guo J, et al. Relationship between vitamin D status and viral pneumonia in children. Pediatr Allerg Immunol Pulmonol. 2017;30(2):86-91.

Mohamed WW, Al-Shehri MA. Cord blood 25-hydroxyvitamin D levels and the risk of acute lower respiratory tract infection in early childhood. J Trop Pediatr. 2012;59(1):29-35.

Najada AS, Habashneh MS, Khader M. The frequency of nutritional rickets among hospitalized infants and its relation to respiratory diseases. J Trop Pediatr. 2004;50(6):364-8.