Intussusception associated with celiac disease in a child: case report and review of literature


  • Mukesh Kumar Department of Pediatrician, Shriram Hospital, Jodhpur, Rajasthan, India
  • Diwakar Bansal Department of General Surgery, Shriram Hospital, Jodhpur, Rajasthan, India
  • Mohan Lal Parihar Department of Radiology, Shriram Hospital, Jodhpur, Rajasthan, India



Celiac disease, Children, Gluten free diet, Intussusception


Intussusception and celiac disease both are common in children.  Intussusception has been rarely associated with celiac disease in children, which mostly involved small bowel, are transient without classical symptoms, reduced spontaneously and rarely needs intervention. Authors are reporting a 2-year girl who presented initially as gastroenteritis and later on intestinal obstruction and on investigation revealed ileo-ileal intussusception which resolved spontaneously during laparotomy preparation. The patient had growth retardation and microcytic hypochromic anemia and on further evaluation diagnosed with celiac disease. This case report highlights the need of celiac testing in children with intussusception, and such intussusception resolved spontaneously with gluten free diet and rarely needs any active intervention, thus preventing from undue nonsurgical or surgical interventions for intussusception.


Branski D, Troncone R, Fasano A. Celiac disease (gluten-sensitive enteropathy). In: Kliegman RM, Stanton BF, St Geme III JW, Schor NF, Behrman RE, eds. Nelson textbook of paediatrics. 20th Ed. Philadelphia, Elsevier; 2016: 1835-37.

Kennedy M, Liacouras CA. Intussusception. In: Kliegman RM, Stanton BF, St Geme III JW, Schor NF, Behrman RE, eds. Nelson textbook of paediatrics. 20th ed. Philadelphia, Elsevier; 2016: 1812-14.

Ruoff M, Linder AE, Marshak RH. Intussusception in sprue. Am J Roentgenol Radium Ther Nucl Med. 1968;104:525-8.

Germann R, Kuch M, Prinz K, Ebbing A, Schindera F. Celiac disease: an uncommon cause of recurrent intussusception. J Pediatr Gastroenterol Nutrit. 1997;25(4):415-6.

Borkar VV, Poddar U, Thakral A, Agarwal J, Srivastava A, Yachha SK, et al. Intussusception in celiac disease: Is it a common feature in children?. J Gastroenterol Hepatol. 2018;33(2):380-4.

Makharia GK, Verma AK, Amarchand R, Bhatnagar S, Das P, Goswami A, et al. Prevalence of celiac disease in the northern part of India: a community-based study. J Gastroenterol Hepatol. 2011;26(5):894-900.

Sood A, Midha V, Sood N, Avasthi G, Sehgal A. Prevalence of celiac disease among school children in Punjab, North India. J Gastroenterol Hepatol. 2006;21(10):1622-5.

Gheibi S. Association between celiac disease and intussusceptions in children: two case reports and literature review. Pediatr Gastroenterol Hepatol Nutrit. 2013;16(4):269-72.

Gonda TA, Cheng J, Lewis SK, Rubin M, Green PH. Association of intussusception and celiac disease in adults. Digest Dis Sci. 2010;55(10):2899-903.

Reilly NR, Aguilar KM, Green PH. Should intussusception in children prompt screening for celiac disease. J Pediatr Gastroenterol Nutr. 2013;56(1):56-9.

Hizal G, Gürakan F, Balamtekın N, Uslu Kizilkan N. Celiac disease presenting with intestinal obstruction: report of two cases. Turk J Gastroenterol. 2012;23:416-7.

Bai YZ, Qu RB, Wang GD, Zhang KR, Li Y, Huang Y, et al. Ultrasound- guided hydrostatic reduction of intussusception by saline enema: a review of 5218 cases in 17 years. Am J Surg. 2006;192:273-5.

Fernandes VP, Lomazi EA, Bellomo-Brandao MA. A rare association of intussusception and celiac disease in a child. Sao Paulo Med J. 2016.

Ludvigsson JF, Nordenskjöld A, Murray JA, Olén O. A large nationwide population-based case-control study of the association between intussusception and later celiac disease. BMC Gastroenterol. 2013;13:89.

Fishman DS, Chumpitazi BP, Ngo PD, Kim HB, Lightdale JR. Small bowel intussusception in celiac disease: revisiting a classic association. J Pediatr Gastroenterol Nutr. 2010;50(3):237.






Case Reports