DOI: http://dx.doi.org/10.18203/2349-3291.ijcp20190685

A study on efficacy of oral administration of colostrum fortified lactoferrin in the weight gain of low birth weight infants

Raghul Jayaseelan, Chidambaranathan Sivaprakasam, Logesvar Palanisamy

Abstract


Background: Low birth weight babies is the result of being small for gestational age (i.e. under 10th percentile of the reference population) and preterm (i.e. before 37 weeks of gestation. Preterm infants have higher protein, calorie requirement, which cannot be met with unfortified breast milk feeds.

Methods: This study was conducted prospectively in the Department of Pediatrics, Rajah Muthiah Medical College and Hospital, Chidambaram from October 2016 to April 2018. 20 low birth weight babies were selected by randomization technique and they were administered with 2 grams of oral colostrum fortified lactoferrin daily for 4 weeks. The rate of weight gain, length gain and head circumference gain were assessed prospectively for a period of 4 weeks. They were analysed statistically by ANOVA and tabulated. Babies weighing less than 2.5 kg and on exclusive breast feeding, were included. Babies more than 2.5kg and less than 1kg, at risk for neonatal sepsis, congenital heart disease, necrotizing enterocolitis were excluded from the study.

Results: In the present study, 20 low birth weight babies were included. 11 maternal risk factors were identified. Out of which anemia stands as a single risk factor. The rate of weight gain in oral colostrum fortified lactoferrin, is 320 grams with P value of 0.703 which is not statistically significant. The rate of length gain is 3.3cm, p value is 0.093 which is statistically insignificant. The rate of head circumference gain in oral colostrum fortified lactoferrin is 2.8cm, with the p-value of 0.001 which is statistically significant.

Conclusions: The rate of weight and length gain was normal, but the rate of head circumference gain is significantly increased in oral colostrum fortified lactoferrin supplementation.


Keywords


Low birth weight, Oral colostrum fortified lactoferrin, Prematurity

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References


Organization WH. International statistical classification of diseases and related health problems, tenth revision, 2nd ed. World Health Organization; 2004.

Fidler N, Koletzko B. The fatty acid composition of the human colostrum. Springer. 2000;133(3):332-40.

Zanin JP, Unsain N, Anastasia A. Role of growth factors and hormones pro-peptides: the unexpected adventures. J Neurochem. 2017;141(3):330-40.

American academy of pediatrics, pediatric Nutrition Handbook. 6th ed. American academy of pediatrics, Washington DC, USA; 2009:79-81.

Harding JE, Wilson J, Brown J. Calcium and phosphorus supplementation of human milk for preterm infants. Cochrane Database of Systematic Reviews. 2017(2).

Polberger S, Räihä NC, Juvonen P, Moro GE, Minoli I, Warm A. Individualized protein fortification of human milk for preterm infants: comparison of ultrafiltrated human milk protein and a bovine whey fortifier. J Pediatr Gastroenterol Nutr. 1999;29(3):332-8.

Dogra S, Thakur A, Garg P, Kler N. Effect of differential enteral protein on growth and neurodevelopment in infants< 1500 g: A randomized controlled trial. J Pediatr Gastroenterol Nutr. 2017;64(5):e126-32.

Ahankari, Myles PR, Dixit JV, Tata LJ, Fogarty AW. Risk factors for maternal anemia and low birth weight in pregnant women living in rural india. F 1000 Res. 2017;6:72.

Willeitner A, Anderson M, Lewis J. Highly concentrated preterm formula as an alternative to powdered human milk fortifier: a randomized controlled trial. J Pediatr Gastroenterol Nutr. 2017;65(5):574-8.

Miller J, Makrides M, Gibson RA, McPhee AJ, Stanford TE, Morris S, et al. Effect of increasing protein content of human milk fortifier on growth in preterm infants born at<31 wk gestation: a randomized controlled trial. Am J Clin Nutr. 2012;95(3):648-55.

Raghuveer TS, McGuire EM, Martin SM, Wagner BA, Rebouché CJ, Buettner GR, et al. Lactoferrin in the preterm infants' diet attenuates iron-induced oxidation products. Pediatr Res. 2002;52(6):964.

Berseth CL, Harris CL, Wampler JL, Hoffman DR, Diersen-Schade DA. Liquid human milk fortifier significantly improves docosahexaenoic and arachidonic acid status in preterm infants. Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA). 2014;91(3):97-103.

Colacci M, Murthy K, DeRegnier RA, Khan JY, Robinson DT. Growth and development in extremely low birth weight infants after the introduction of exclusive human milk feedings. Am J Perinatol. 2017;34(02):130-7.

Porcelli P, Schanler R, Greer F, Chan G, Gross S, Mehta N, et al. Growth in human milk-fed very low birth weight infants receiving a new human milk fortifier. Ann Nutri Metabol. 2000;44(1):2-10.