Clinical course of dilated cardiomyopathy in children

Authors

  • Sivakumar E. Department of Paediatrics, Institute of Child Health and Research Centre, Government Rajaji Hospital, Madurai Medical College, Madurai, Tamil Nadu, India
  • Ramasubramaniam P. Department of Paediatrics, Institute of Child Health and Research Centre, Government Rajaji Hospital, Madurai Medical College, Madurai, Tamil Nadu, India

DOI:

https://doi.org/10.18203/2349-3291.ijcp20190501

Keywords:

Cardiomyopathy, Cardiothoracic diameter, Ejection fraction

Abstract

Background: Dilated cardiomyopathy (DCM) in children is a serious disorder. Here authors study the risk factors for predicting prognosis of dilated cardiomyopathy in children.

Methods: An observational case series study done in Institute of child health and research centre, Government Rajaji hospital, Madurai during September 2012 to August 2014. The diagnosis of DCM was based on clinical examination and echocardiographic evidence. Patients were followed up and grouped according to the outcome as improved or cured (group I), no change in clinical status (group II) and worsened or dead (group III).

Results: 31 children less than 12 years of age were diagnosed as DCM. 13 children came under group I with a mean age of 2.15±2.5 and the mean cardiothoracic diameter ratio in chest X-ray was 59.8±3.3. The mean left ventricular ejection fraction at the time of admission was 38.7±3.04 and was 52.1±2.7 on last follow up. 11 children came under Group III with a mean age of 5.35±4.4 and the mean cardiothoracic diameter ratio was 65.3±2.7. The mean left ventricular ejection fraction was 35.8±3.7 at admission and 32.6±2.9 on last follow up. Only two children came under Group II and hence their comparison is negligible.

Conclusions: Children with higher age at the time of diagnosis, higher cardiothoracic diameter ratio in chest X-ray and a low left ventricular ejection fraction on serial echocardiogram were associated with a poor outcome.

Metrics

Metrics Loading ...

References

Fujioka S, Kitaura Y, Ukimura A, Deguchi H, Kawamura K, Isomura T, et al. Evaluation of viral infection in the myocardium of patients with idiopathic dilated cardiomyopathy. J Am Coll Cardiol. 2000;36(6):1920-6.

Kasper EK, Agema WR, Hutchins GM, Deckers JW, Hare JM, Baughman KL. The causes of dilated cardiomyopathy: a clinicopathologic review of 673 consecutive patients. J Am Coll Cardiol. 1994;23(3):586-90.

Arola A, Jokinen E, Ruuskanen O, Saraste M, Pesonen E, Kuusela AL, et al. Epidemiology of idiopathic cardiomyopathies in children and adolescents: a nationwide study in Finland. Am J Epidemiol. 1997;146(5):385-93.

Daubeney PE, Nugent A, Davis AM, Wilkinson JL, Weintraub RG. Incidence and outcome of childhood cardiomyopathy in Australia: results of a ten-year population-based study. J Am Coll Cardiol. 1999;33(suppl A):496A.

Keeling PJ, Gang Y, Smith G, Seo H, Bent SE, Murday V, et al. Familial dilated cardiomyopathy in the United Kingdom. Heart. 1995;73(5):417-21.

Michels VV, Moll PP, Miller FA, Tajik AJ, Chu JS, Driscoll DJ, et al. The frequency of familial dilated cardiomyopathy in a series of patients with idiopathic dilated cardiomyopathy. New England J Med. 1992;326(2):77-82.

Kothari SS, Sharma M. L-carnitine in children with idiopathic dilated cardiomyopathy. Indian Heart J. 1998;50(1):59-61.

Griffin ML, Hernandez A, Martin TC, Goldring D, Bolman RM, Spray TL, et al. Dilated cardiomyopathy in infants and children. J Am Coll Cardiol. 1988;11(1):139-44.

Chen SC, Nouri S, Balfour I, Jureidini S, Appleton RS. Clinical profile of conjestive cardiomyopathy in children. J Am Coll Cardiol. 1990;15(1):189-93.

Akagi T, Benson LN, Lightfoot NE, Chin K, Wilson G, Freedom RM. Natural history of dilated cardiomyopathy in children. Am Heart J. 1991;121(5):1502-6.

Friedman RA, Moak JP, Garson A. Clinical course of idiopathic dilated cardiomyopathy in children. J Am Coll Cardiol. 1991;18(1):152-6.

Colan SD, Parness IA, Spevak PJ, Sanders SP. Developmental modulation of myocardial mechanics: age-and growth-related alterations in afterload and contractility. J Am Coll Cardiol. 1992;19(3):619-29.

Kothari SS, Dhopeshwarkar RA, Saxena A, Juneja R. Dilated cardiomyopathy in Indian children. Indian Heart J. 2003;55(2):147-51.

Nugent AW, Daubeney PE, Chondros P, Carlin JB, Cheung M, Wilkinson LC, et al. The epidemiology of childhood cardiomyopathy in Australia. New Eng J Med. 2003;348(17):1639-46.

Strauss A, Lock JE. Pediatric cardiomyopathy-a long way to go. N Eng J Med. 2003;348:1703-5.

Jokinan E. Idiopathic dilated cardiomyopathy in children prognostic indicators and outcome. Pediatrics. 1998;101:369-76.

Downloads

Published

2019-02-23

How to Cite

E., S., & P., R. (2019). Clinical course of dilated cardiomyopathy in children. International Journal of Contemporary Pediatrics, 6(2), 468–472. https://doi.org/10.18203/2349-3291.ijcp20190501

Issue

Section

Original Research Articles