Langerhans cell histiocytosis presenting as isolated central diabetes insipidus in a 2-year-old child: a rare manifestation of rare disease

Authors

  • Nirmal S. R. Department of Pediatrics, Sri Manakula Vinayagar Medical College and Hospital, Puducherry, Tamil Nadu, India
  • Revathi Krishnakumar Department of Pediatrics, Sri Manakula Vinayagar Medical College and Hospital, Puducherry, Tamil Nadu, India
  • Gayathri G. Nair Department of Pediatrics, Sri Manakula Vinayagar Medical College and Hospital, Puducherry, Tamil Nadu, India
  • Sri Lakshmi Chordia Department of Pediatrics, Sri Manakula Vinayagar Medical College and Hospital, Puducherry, Tamil Nadu, India
  • Arulkumaran Arunagirinathan Department of Pediatrics, Sri Manakula Vinayagar Medical College and Hospital, Puducherry, Tamil Nadu, India

DOI:

https://doi.org/10.18203/2349-3291.ijcp20192050

Keywords:

Children, Central diabetes insipidus, Langerhans cell histiocytosis

Abstract

Central diabetes insipidus, though uncommon in children, has varied causes, the commonest ones being genetic mutations, infiltrative disorders, infections. Isolated central diabetes insipidus is not one of the often encountered conditions in the pediatric practice. Here we report a case of 2 ½ years old female child who presented to us following history of polyuria for 2 months, who was confirmed to have central diabetes insipidus which was later evaluated to be secondary to Langerhans cell histiocytosis. Magnetic resonance imaging (MRI) and histopathological studies further helped in confirmation of the diagnosis. Langerhans cell histiocytosis is a rare, multifarious, and underdiagnosed hematologic disease in which isolated diabetes insipidus can be the sole presenting feature before other manifestations. Hence, this diagnosis could strongly be considered in the work up of central diabetes insipidus in children.

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References

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Published

2019-04-30

How to Cite

R., N. S., Krishnakumar, R., Nair, G. G., Chordia, S. L., & Arunagirinathan, A. (2019). Langerhans cell histiocytosis presenting as isolated central diabetes insipidus in a 2-year-old child: a rare manifestation of rare disease. International Journal of Contemporary Pediatrics, 6(3), 1386–1390. https://doi.org/10.18203/2349-3291.ijcp20192050

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Section

Case Reports