Nutritional and haematological status of human immunodeficiency virus infected children


  • Chandra M. Pandey Department of Pediatrics, S. N. Children Hospital, M. L. N. Medical College Allahabad, Uttar Pradesh
  • Anubha Shrivastava Department of Pediatrics, S. N. Children Hospital, M. L. N. Medical College Allahabad, Uttar Pradesh



Children, Haematological status, HIV infection, Nutritional status


Background:Under nutrition and anaemia are among the commonest presenting signs in human immunodeficiency virus (HIV) infected children. Cause could be multi factorial. HIV infection itself may produce this situation. Opportunistic infections, nutritional deficiencies and bone marrow suppression due to various factors could be the other reasons. To study the nutritional and haematological status in HIV infected children this study was undertaken.

Methods: 140 children of both sexes, between the age 18 months to 15 years, who were diagnosed HIV positive as per guide lines of national AIDS control organization of India, were included in this study. Their anthropometric, general and systemic examinations were done. Haematological investigations including complete blood count (CBC), general blood picture (GBP), CD4 count was done in all cases. They were classified in clinical and immunological staging according to WHO classification criteria. Bone marrow aspiration was performed in 43 children. They were investigated for suspected opportunistic infections as well.

Results:Out of 140 chidren, 91 were male and 49 were female. 47 children were orphan and 111 children were in low socioeconomic status. 101 children were significantly under nourished. No child was nutritionally normal. Clinical signs of vitamin A and D deficiency was seen in 21 and seven children respectively. 85% children were anaemic and most common morphology was normocytic normochromic blood picture. Lymphopenia was seen in 43.57%, granulocytopenia in 48.57% and thrombocytopenia in 30.71% children. There was no significant finding in bone marrow examination.

Conclusions:This study concludes that in children, commonest route of infection was vertical transmission. Mean age of presentation was 7.67 years. Varying degree of mal nutrition and anaemia was noted in more than 85% HIV infected children. No child was nutritionally normal.


Ira Shah. Age related Clinical manifestations of HIV infection in Indian children. J Trop Pedia. 2005;51(5):300-3.

WHO and UNAIDS annual report, December 2008. Available at http:// /pub/ Report /2009/jc1736_ 2008_ annual_ report_en. pdf. Accessed on 12 March 2016.

Madhivanan P, Mothi SN, Kumarassamy N, Yepthomi T. Clinical manifestations of HIV infected children. Indian J Pedia. 2001;70:615-20.

Merchant RH, Oswal JS, Bhagwat RV, Karkare J. Clinical profile of HIV infection. Indian Pediatr. 2001;38:239-46.

Mir N, Costello C, Luckit J, Lindley R. HIV disease and bone marrow changes: a study of 60 cases. Eur J Haematol. 1998;42(4):339-43.

Claster S. Biology of anaemia, differential diagnosis and treatment options in human immunodeficiency virus infection. J Infect Dis. 2002;185(2):105-9.

Karande S, Bhalke S, Kelkar A, Ahuja S. Utility of clinically derected selective screening to diagnose HIV infection in hospitalized children in Mumbai. India J Trop Pediatr. 2002;48:149-55.

Mohandas, Sehgal R, Sud A, Malla N. Prevalence of intestinal parasitic pathogens in HIV seropositive individuals in Northern India. J Infect Dis. 2002;55:83-4.

Agarwal D, Chakravarty J, Sundar S, Gupta V. Co-relation between clinical features and degree of immune suppression in HIV infected children. Indian Pediatr. 2008;45(2):140-3.

Shet A, Mehta S, Rajagopalan N, Dinaker C. Anaemia and growth failure among HIV infected children in India: a retrospective analysis. BMC Pediatr. 2009;9:3.

Kumarasamy N, Solomon S, Flanigan TP, Hemalatha R. Natural history of human immunodeficiency virus disease in southern India. Clin Inf Dis. 2003;36:79-85.

Lodha R, Upadhyay A, Kabra SK. Anti-retroviral therapy in HIV infected children. Indian Pedia. 2005;42:789-95.

Belperio PS, Rhew DC. Prevalence and outcome of anaemia individuals with human immunodeficiency virus: a systemic review of the literature. Am J Med. 2004;116(7):27-43.

Moller T, Hasselbalch HC. Hematological changes associated with human immunodeficiency virus (HIV-I) infection. Ugeskr Laeger. 1993;155(19):1442-6.

Saurez AD, Rao SP, Miller ST. Prevalence of lymphopenia in children with AIDS. Clin Pediatr. 1994;33(4):204-8.

Silva EB, Silva MT, Vilela MM. Evaluation of haematological parameters in a group of children with human immunodeficiency virus infection HIV-I. J Pediatr. 1999;75(6):442-8.

Adewuyi J, Chitsike I. Haematologic features of the human immune deficiency virus (HIV) infection in black children in Harare. Cent Afr J Med. 1994;40(12):333-6.






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