Comparison of the efficacies of normal saline versus hypertonic saline in the management of acute bronchiolitis’

Oya Koker; Sebnem Ozdogan; Gulsen Kose; Zeynep Y. Yildirmak

doi:10.18203/2349-3291.ijcp20162353

Authors

Oya Koker Department of Pediatrics, Sisli Hamidiye Etfal Research and Training Hospital, İstanbul
Sebnem Ozdogan Department of Pediatrics Pulmonology, Sisli Hamidiye Etfal Research and Training Hospital, İstanbul
Gulsen Kose Department of Pediatrics, Sisli Hamidiye Etfal Research and Training Hospital, İstanbul
Zeynep Y. Yildirmak Department of Pediatrics, Sisli Hamidiye Etfal Research and Training Hospital, İstanbul

DOI:

https://doi.org/10.18203/2349-3291.ijcp20162353

Keywords:

Bronchiolitis, Hypertonic saline solution, Respiratory syncytial virus

Abstract

Background: The aim of this study was to compare the efficacies of saline solutions of different concentrations used for the management of infants with mild to moderate bronchiolitis.

Methods: A retrospective chart review of 46 children, aged 1-24 months, diagnosed with acute bronchiolitis was performed. The patients were separated into 2 groups: normal saline and 3% hypertonic saline. Length of hospital stay, modified respiratory assessment score (MRAS) at admission, at 48 hours of admission and at discharge were compared.

Results: MRAS evaluated at admission, at 48 hours after admission and at discharge and length of hospital stay did not reveal significant difference between the two groups (p>0.05).

Conclusions: Comparison of two different treatments, salbutamol applied in combination with either normal saline or 3% hypertonic saline, did not reveal any statistically significant differences with respect to symptomatic improvement or length of hospital stay.

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References

Goodman D. Inflammatory disorders of the small airways: Bronchiolitis. In: Behrman RE, Kliegman RM, Jenson HB, eds. Nelson Textbook of Pediatrics, 17th ed.Philadelphia: Saunders. 2004:1415-17.

Samina A. Bronchiolitis. In: Chernick V, Boat TF, eds. Kendig’s Disorders of the Respiratory Tract in Children, 7th ed. Philadelphia:WB Saunders. 2006:443-452.

Yalçın E, Karadağ B, Uzuner N. Turkish Thoracic Society – Acute Bronchiolitis: Diagnosis,Treatment and Prevention. Turkish Thoracic Journal. 2009;10(Suppl 1):7-9.

Hacımustafaoğlu M, Celebi S, Bozdemir SE, Ozgür T, Ozcan I, Güray A. RSV frequency in children below 2 years hospitalized for lower respiratory tract infections. Turk J Pediatr. 2013;55(2):130-9.

Reynolds EO, Cook CD. The treatment of bronchiolitis. J Pediatr. 1963;63:1205-7.

Mandelberg A, Amirav I. Hypertonic saline or high volume normal saline for viral bronchiolitis: mechanisms and rationale. Pediatr Pulmonol. 2010;45:36-40.

Sarrell EM, Tal G, Witzling M. Nebulized 3% hypertonic saline solution treatment in ambulatory children with viral bronchiolitis decreases symptoms. Chest. 2002;122: 2015-20.

Kuzik BA, Al-Qadhi SA, Kent S. Nebulized hypertonic saline in the treatment of viral bronchiolitis in infants. J Pediatr. 2007;151:266-70.

McIntosh K. Respiratory syncytial virus. In: Behrman RE, Kliegman RM, Jenson HB, editors. Nelson Textbook of Pediatrics. 18th ed. Philadephia: WB Saunders. 2007;1388-90.

American Academy of Pediatrics Subcommittee on Diagnosis and Management of Bronchiolitis. Diagnosis and management of bronchiolitis. Pediatrics. 2006;118(4):1774-93.

Scottish Intercollegiate Guidelines Network (SIGN). Bronchiolitis in children. (A national clinical guideline.) 2006. www.sign.ac.uk.

Eber E. Treatment of acute viral bronchiolitis. Open Microbiol J. 2011;5:159-64.

Nagakumar P, Doull I. Current therapy for bronchiolitis. Arch Dis Child. 2012;97:827-30.

Zorc JJ, Hall CB. Bronchiolitis: Recent Evidence on Diagnosis and Management. Pediatrics. 2010;125:342.

Mandelberg A, Tal G, Witzling M. Nebulized 3% hypertonic saline solution treatment in hospitalized infants with viral bronchiolitis. Chest. 2003;123:481-7.

Tal G, Cesar K, Oron A, Houri S, Ballin A, Mandelberg A. Hypertonic saline/epinephrine treatment in hospitalized infants with viral bronchiolitis reduces hospitalization stay: 2 years experience. Isr Med Assoc J. 2006;8:169-73.

Zhang L, Mendoza-Sassi RA, Wainwright C, Klassen TP. Nebulized hypertonic saline solution for acute bronchiolitis in infants. Cochrane Database Syst Rev. 2008;4.

Mahesh Kumar KB, Karunakara BP, Manjunath MN, Mallikarjuna HB. Aerosolised hypertonic saline in hospitalized young children with acute bronchiolitis: a randomized controlledclinical trial. Journal of Pediatric Sciences. 2013:5(1).

Sharma BS, Gupta MK, Rafik SP. Hypertonic (3%) saline vs 0.93% saline nebulization for acute viral bronchiolitis: a randomized controlled trial. Indian Pediatr. 2013;50(8):743-7.

Martín Martín R, Yep Chullen G, Sánchez Bayle M, Villalobos Pinto E, Flores Pérez P. Nebulized 3% hypertonic saline solution in hospitalized infants with acute bronchiolitis: case-control study on the utility and effectiveness. Rev Pediatr Aten Primaria. 2013;15:109-15.