Changing trends in clinicopathological parameters in dengue with evaluation of predictors of poor outcome in children

Smita Ramachandran, Akriti Gera, Murtaza Kamal, Rani Gera, Manas Pratim Roy


Background:A study was planned to evaluate the changing trends in dengue according to the revised WHO guidelines in children and at identifying and evaluating the association between clinical features the child and the outcome.

Methods: This was a retrospective observational study conducted in Safdarjung Hospital. Children with signs and symptoms of dengue fever along with serological or antigen NS1 positivity were included. Continuous variables were analysed using percentage, mean, standard deviation. Categorical variables were analysed using chi-square test. P value < 0.05 was considered significant.

Results:A total number of 69 patients of dengue were included. The mean age of presentation was 7.1±3 years. All patients with mucosal bleeds had thrombocytopenia which was statistically significant (p<0.002). There was a significant correlation (p < 0.000) between presence of more than three warning signs and prolonged hospital stay (>5 days) (p < 0.000) and progression to shock.

Conclusions:Lethargy, presence of more than 3 warning signs at the time of presentation can be used as predictors of severe dengue.  


Changing trends dengue, Clinicopathological parameters, Pediatrics, Prognostic factors, Poor outcomes

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