Correlation of clinical and laboratory parameters of acute glomerulonephritis in children

Chandra Sekhar Kondapalli, Kalyan Chakravarthy Gondi, Faisal Mohammed


Background: The present study was conducted to study the clinical and laboratory parameters of acute glomerulonephritis in children admitted in the department of Pediatrics, Katuri Medical College and Hospital, Guntur.

Methods: A prospective study was done at Katuri Medical College and Hospital in all children who are clinically diagnosed edema, oliguria, Cola coloured urine and hypertension. Children presenting with Oliguria, Oedema, Haematuria, Hypertension, Pharyngitis or skin lesions were included, both genders male and female. 50 cases of post-streptococcal glomerulonephritis were evaluated by taking detailed history, thorough clinical examination and appropriate investigation were done for establishment of diagnosis. Lab investigations, CUE, RFT, ASO titres, Serum Complement were done. All the statistical analysis was performed by using EPI INFO 3.5-1. The results were expressed as percentages. Test of significance was done by chi square test. P<0.05 was considered significant.

Results: 4156 cases were admitted, out of which 50 cases were having acute glomerulonephritis comprising of 1.2%. The incidence of glomerulonephritis was more from July to December. The sex ratio from male to female is 1.17:1. The incidence of glomerulonephritis was more in children coming from low socio-economic families. Signs wise analysis of glomerulonephritis, it was observed that puffiness of face, edema feet and hypertension were the common features. Incidence of hyper tension were more in male children than female children. The incidence of edema and proteinuria are the commonest clinical presentation. The comparison between incidence of oliguria and blood urea is statistically significant. 1/4th of patients of oliguria are associated with increase serum creatinine level.

Conclusions: Acute glomerulonephritis is completely a preventable and completely curable disease if proper precaution is like personal hygiene is observed. Proper knowledge of pathophysiology of glomerulonephritis is important for proper management, institution on appropriate treatment and careful follow up of cases are the corner stones for successful outcome of patients.


AGN clinical and labs, AGN in children, Correlation of AGN

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Banapurmath CR, Zacharias TS, Somashekhar KS, Abdul Nazer PU. Congestive cardiac failure and electrocardiographic abnormalities in acute glomerulonephritis. Indian Pediatr. 1996;33:589-92.

Carapetis JR, Steer AC, Mullholand EK, Weber M. The global burden of group A streptococcal diseases. Lancet. 2005;5:685-94.

Madaio MP, Harrington JST. Current concept of acute glomerulonephritis in children's hospital. BOSTON. 2001;161(1):25-34.

Cynthia G. Pan, Ellis D. Avner, eds. Acute glomerulonephritis‖. Nelson text book Pediatrics. 20th ed. Elsevier inc; 2016.

Arvind Bagga, Shina Menon. Acute glomerulonephritis. In: Pediatric Nephrology text book. 6th ed; 2016.

Malculma, Holliday, Martin Barratt, Ellisd Aumer, Pediatric Nephrology. 3rd ed; 1994:697.

Kanjanabuch T, Kittikowit W, Eiam-Ong S. An update on acute postinfectious glomerulonephritis worldwide. Nat Rev Nephrol. 2009;5(5):259-69.

Srivastava RN. Acute glomerulonephritis. Indian J Pediatr. 1999;66(2):199-205.

Manhas RS, Patwari A, Raina C, Singh A. Acute nephritis in Kashmiri children-a clinical and epidemiological profile (a study of 350 cases). Indian Pediatr. 1979;16(11):1015-21.

Anochie I, Eke F, Okpere A. Childhood acute glomerulonephritis in Port Harcourt, Rivers State, Nigeria. Nigerian J Med: J e National Ass Resident Doctors Nigeria. 2009;18(2):162-7.

Ugwu GM. Acute glomerulonephritis in children of the Niger Delta region of Nigeria. Saudi J Kidney Dis Transplantation. 2015;26(5):1064.

Etuk IS, Anah MU, Eyong ME. Epidemiology and clinical features of glomerulonephritis in Calabar, Nigeria. Niger J Physiol Sci. 2009;24:91-4.

Kumar GV. Clinical study of post streptococcal acute glomerulonephritis in children with special reference to presentation. Current Pediatric Res. 2011;15(2).

Okoro BA, Okafor HU. Pattern of childhood renal disorders in Enugu. Nig J Paediatr. 1999;26:14-8.

Dodge WF, Spargo BH, Travis LB, Srivastava RN, Carvajal HF, DeBeukelaer MM, et al. Poststreptococcal glomerulonephritis. A prospective study in children. N Engl J Med. 1972;286:273-8.

Yadav SP, Shah GS, Mishra OP, Baral N. Pattern of renal diseases in children: a developing country experience. Saudi J Kidney Dis Transplant. 2016;27(2):371.

Singh ME, Qureshi AMA. Clinical profile of acute glomerulonephritis in children. Indian J Paediatr. 1984;51:553-7.

Berrios X, Lagomarsino E, Solar E, Sandoval G, Guzman B, Riedel I. Post-streptococcal acute glomerulonephritis in Chile-20 years of experience. Pediatr Nephrol. 2004;19:306-12.

Ocheke IE, Okolo SN, Thomas FB, Agaba EI. Pattern of Childhood Renal Diseases in J OS, Nigeria: A Preliminary Report. J Med Tropics. 2010;12:5255.

Shah GS. Clinical profile and outcome of Acute Glomerulonephritis in a tertiary care center in the eastern Nepal. Institute Med. 2014;36:1.

Poon-king T, Mohammed I, Cox R, Potter EV, Simon NM, Siegel AC, et al. Recurrent epidemic nephritis in south Trinidad. New Engl J Jlied. 1967;277:728.

Ibadin PO, Abiodun PO. Childhood acute glomerulonephritis in Benin City. Nig J Paediatr. 2003;30:45-9.

Becquet O, Pasche J, Gatti H, Chenel C, Abély M, Morville P, et al. Acute post-streptococcal glomerulonephritis in children of French Polynesia: a 3-year retrospective study. Pediatr Nephrol. 2010;25(2):275.

Derakhshan A, Hekmat VR. Acute Glomerulonephritis in Southern Iran. Iran J Pediatr. 2008;18(2):143-8.