Assessment of epidemiological profile of neonatal seizure cases admitted to a tertiary health center of Odisha, India: a cross-sectional study
Keywords:HIE, Morbidity, Neonates, Risk factors, Seizure
Background: Neonatal seizures are common manifestations of neurologic dysfunction in newborns. The incidence of seizures in neonatal period is higher than any other period of life. It is one of the common causes of admission to special newborn care unit. Therefore, it has been decided to assess the epidemiological profile of neonatal seizure.
Methods: A cross-sectional study was conducted from January2017 to June 2018, in the SNCU of MKCG Medical College and Hospital, Berhampur. A total of 300 neonates admitted to SNCU with clinically apparent seizure were the study population and convenient sampling method was used for selecting them. The approval was taken from IEC MKCG Medical College to carry out the study. The data was collected by using a pretested proforma from parents and hospital records. Verbal informed consent was taken from parents. The data so collected was analysed in the department of Pediatrics.
Results: Out of the total 300 babies, 66% were males, 61.34% were early neonates,77% babies were of primi mothers,76% of babies were outborn . 62.12% of babies were born by vaginal route. HIE was most common (88%) cause of seizure. Out of the all seizure types, subtle seizure was most common (87.67%), followed by clonic seizure (35.67%). Various maternal risk factors were present in 81.81 % of cases. Most common risk factor was anemia (50.57%).18.93% of cases were born with history of obstructed labor/prolonged labor. Overall mortality was 8%.
Conclusions: Neonatal seizures are important causes of morbidity and mortality in newborns. Prevention of HIE and maternal risk factors along with early use of an effective drug with minimum side effects are the ways to overcome this problem.
Mohamad A. Mikati and Abeer J. Hani Neonatal Seizure, Nelson Text book of Pediatrics 20th Edition 2016, 593.7 p-2849-2854
Report of the National Neonatal Perinatal Database (National Neonatology Forum, India 2000) Available at: http://www.newbornwhocc.org/pdf/nnpd_report_2002-03.PDF
CENSUS 2011 Available at: http://www.censusindia.gov.in/2011census/population_enumeration.html
Sedighi M, Asadi F, Moradian N, Vakiliamini M, Moradian M. Efficacy and safety of levetiracetam in the management of seizures in neonates. Neurosciences (Riyadh). 2016;21(3):232-5.
Kadivar M, Mohammadi M, Mosayebi Z, Shervinbadv R, Sangsari R, Yarali B. Effect of Levetiracetam in the Treatment of Refractory Seizure in Infants through EEG: The Case of the Neonatal Intensive Care Unit of Tehran’s Children’s Medical Center. British J Pharmaceut Res. 2017;18(1).
Singh KS, Sengar GS. A study of multiorgan dysfunction in asphyxiated neonates. Int J Contemp Pediat. 2016;3(2):625-30.
Patra C, Sarkar S, Dasgupta MK. Study of hepatic enzyme activity as a predictor of perinatal asphyxia and its severity and outcome. Indian J Health Sci 2016;9(3):297-302
Reddy BS, Reddy UN, Nagasravani J, Nasir M. Incidence of Acute Renal Failure in Birth Asphyxia and its Correlation with Hypoxic Ischemic Encephalopathy (HIE). Int J Med Res and Health Sci. 2017;6(4):80-91
Vemuri A, Lalwani S multi organ dysfunction in term neonates with perinatal asphyxia. J Nepal Paediatr Soc. 2015;35(3):307-11
Mohammed Lh, Khairy Ma, El-Hussieny Na, Zaazou Mh, Aly Rm. Multi organ dysfunction in neonates with hypoxic ischemic encephalopathy, Med J Cairo Univ. 2010;78(1);461-7.