Comparative study of rise of vitamin D in hypovitaminosis D babies after two different dosage recommendations
Keywords:Hypocalcemia, Rickets, Vitamin D deficiency
Background: There are currently two different guidelines for treatment of Vitamin D deficiency in infants, one is that of American Academy of Pediatrics and the other being Clinical Practice Guidelines of the Endocrine Society. This study was done to compare the two guidelines for treatment of Vitamin D deficiency in infants.
Methods: A hospital based, longitudinal interventional study was conducted for 2 years and 115 babies having vitamin d deficiency (Vitamin D less than or equal to 20ng/dl) were divided into group A and group B. Group A babies were treated as per American Academy of Pediatrics Guidelines whereas Group Cases were treated as per International Endocrine Society guidelines. All babies were followed up after 3-4 months when repeat Vitamin D levels were checked and then compared.
Results: In present study, Vitamin D level had increased by 0.6 times in Group A whereas it had increased by 1.3 times in group B and it was significant.
Conclusions: Study results were in favour of the guidelines recommended by the International Endocrine Society.
Calvo MS, Whiting SJ, Barton CN. Vitamin D intake: a global perspective of current status. J Nutr. 2005;135(2):310-6.
Agarwal N, Faridi MM, Aggarwal A, Singh O. Vitamin D Status of term exclusively breastfed infants and their mothers from India. Acta Paediatrica. 2010;99(11):1671-4.
Gupta A. Vitamin D deficiency in India: prevalence, causalities and interventions. Nutr. 2014;6(2):729-75.
Hazell TJ, DeGuire JR, Weiler HA. Vitamin D: an overview of its role in skeletal muscle physiology in children and adolescents. Nutri Rev. 2012;70(9):520-33.
Dawodu A, Tsang RC. Maternal vitamin D status: effect on milk vitamin D content and vitamin D status of breastfeeding infants. Adv Nutr. 2012;3(3):353-61.
Meena P, Dabas A, Shah D, Malhotra RK, Madhu SV, Gupta P. Sunlight exposure and vitamin D status in breastfed infants. Indian Pediatr. 2017;54(2):105-11.
Abrams SA. Calcium absorption in infants and small children: methods of determination and recent findings. Nutr. 2010;2(4):474-80.
Camadoo L, Tibbott R, Isaza F. Maternal vitamin D deficiency associated with neonatal hypocalcaemic convulsions. Nutr J. 2007;6(1):23.
Pettifor JM. Nutritional rickets: deficiency of vitamin D, calcium, or both?. Am J Clinic Nutr. 2004;80(6):1725S-9S.
Armstrong C. AAP doubles recommended vitamin D intake in children. Am Fam Phys. 2009;80(2):196-8.
Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clinic Endocrinol Metabol. 2011;96(7):1911-30.
Stroud ML. Vitamin D - a review. Aust Fam Physician. 2008;37(12):1002-5.
Thacher TD, Fischer PR, Strand MA, Pettifor JM. Nutritional rickets around the world: causes and future directions. Ann Trop Paediatr. 2006;26:1-16.
Dawodu A, Wagner CL. Prevention of vitamin D deficiency in mothers and infants worldwide-a paradigm shift. Paediatr Int Child Heal. 2012;32(1):3-13.
Wagner CL, Greer FR. Prevention of rickets and vitamin D deficiency in infants, children, and adolescents. Pediatr. 2008;122:1142-52.