Non-rhabdomyosarcoma soft tissue sarcoma in a neonate, a rare and aggressive disease: case report

Tanvi Khanna; Kunal Das; B. P. Kalra

doi:10.18203/2349-3291.ijcp20185211

Authors

Tanvi Khanna Division of Pediatric Oncology, Cancer Research Institute, Swami Rama Himalayan University, Jolly Grant, Dehradun, Uttarakhand, India
Kunal Das Division of Pediatric Oncology, Cancer Research Institute, Swami Rama Himalayan University, Jolly Grant, Dehradun, Uttarakhand, India
B. P. Kalra Division of Pediatric Oncology, Cancer Research Institute, Swami Rama Himalayan University, Jolly Grant, Dehradun, Uttarakhand, India

DOI:

https://doi.org/10.18203/2349-3291.ijcp20185211

Keywords:

Abdominal wall tumor, Neonatal soft tissue sarcoma, Neonatal cancer, Non-rhabdomyosarcoma soft tissue sarcoma

Abstract

Neonatal soft tissue sarcomas are a rare group of tumors. The behavior and aggressiveness of neonatal STS is variable. Surgical excision has been noted to be most important factor affecting outcome. However, when non-mutilating surgery is not possible, or resection is incomplete, chemotherapy and radiotherapy have been tried with variable success. We encountered a case of a neonate having large soft tissue mass at anterior abdominal wall. Biopsy and immunohistochemistry confirmed it as undifferentiated soft tissue sarcoma. Surgical excision was incomplete with margin positivity. His disease showed recurrence in short duration of time and despite adjuvant chemotherapy, progression was noted. The child abandoned the treatment and died within 3 months of life.

Metrics

Metrics Loading ...

References

M, Jarreau PH, Tsatsaris V, et al. Neonatal cancer. Lancet Oncol. 2013;14(13):e609-20.

Orbach D, Rey A, Oberlin O, Sanchez de Toledo J, Terrier-Lacombe MJ, Van Unnik A, et al. Soft Tissue Sarcoma or Malignant Mesenchymal Tumors in the First Year of Life: Experience of the International Society of Pediatric Oncology (SIOP) Malignant Mesenchymal Tumor Committee. J Clin Oncol. 2005;23(19):4363-71.

Valind A, Öra I, Mertens F, Gisselsson D. Neuroblastoma with flat genomic profile: a question of representativity? BMJ case reports. 2018;2018:bcr-2018.

Restrepo R, Francavilla ML, Mas R, Lee EY, et al. Up-To-Date Practical Imaging Evaluation of Neonatal Soft-Tissue Tumors: What Radiologists Need to Know. AJR. 2017;209(1):195-204.

Orbach D, Rey A, Cecchetto G, Oberlin O, Casanova M, Thebaud E, Scopinaro M, Bisogno G, Carli M, Ferrari A. Infantile fibrosarcoma: management based on the European experience. J Clinic Oncol. 2009;28(2):318-23.

Orbach D, Brennan B, De Paoli A, Gallego S, Mudry P, Francotte N, et al. Conservative strategy in infantile fibrosarcoma is possible: The European paediatric Soft tissue sarcoma Study Group experience. European J Cancer. 2016;57:1-9.

Fernandez-Pineda I, Neel MD, Rao BN. Current Managament of Neonatal Soft- tissue Sarcomas and Benign Tumors with local aggressiveness. Curr Pediatr Rev. 2015;11(3):216-25.

Ferrari A, Orbach D, Sultan I, Casanova M, Bisogno G. Neonatal soft tissue sarcomas. InSeminars in Fetal and Neonatal Medicine 2012 Aug 1 (Vol. 17, No. 4, pp. 231-238). WB Saunders.

Chandrasekaran A. Neonatal Solid Tumours. Pediatr and Neonatol. 2018;59(1):65-70

Berbel Tornero O, Ferrís i Tortajada J, Donat Colomer J, Muñoz Guillén A, Verdeguer Miralles A, Ortega García J. et al. Neonatal tumours: clinical and therapeutic characteristics- analysis of 72 patients in La Fe University Childrens Hospital in Valencia (Spain) [in Spanish]. An Pediatr (Barc) 2006;65(2):108-17.