DOI: http://dx.doi.org/10.18203/2349-3291.ijcp20163676

Vitamin A supplementation for prevention of bronchopulmonary dysplasia in very low birth weight infants

Mahima Mittal, Bhoopendra Sharma

Abstract


Background: Vitamin A maintains the integrity of epithelial cells of the respiratory tract and is an essential element for normal lung growth. The aim was to assess the effectiveness of vitamin A supplementation in very low birth weight (VLBW) infants to prevent development of bronhopulmonary dysplasia (BPD).

Methods: This was a retrospective cohort study to determine the effectiveness of vitamin A in preventing complications of prematurity in VLBW infants. Vitamin A was delivered intramuscularly at a dose of 5000 IU, three times weekly during the first 28 days of life.

Results:Of the 142 eligible VLBW infants, 60 VLBW infants received the vitamin supplement. We observed a significant difference between the groups in the duration of oxygen therapy or in the risk of bronchopulmonary dysplasia. Serum vitamin A levels were significantly raised in those who were supplemented.

Conclusions:Given the significant difference in development of BPD, days of oxygen therapy and days of ventilation, it is advisable to use Vitamin A supplementation in VLBW babies.  


Keywords


BPD, Vitamin A, VLBW

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References


Spears K, Cheney C, Zerzan J. Low plasma retinol concentrations increase the risk of developing bronchopulmonary dysplasia and long-term respiratory disability in very-low-birth- weight infants. Am J Clin Nutr. 2004;80:1589-94.

Shenai JP, Kennedy KA, Chytil F, Stahlman MT. Clinical trial of vitamin A supplementation in infants susceptible to bronchopulmonary dysplasia. J Pedia. 1987;111:269-77.

Northway WH, Rosan RC, Porter DY. Pulmonary disease following respiratory therapy of hyaline-membrane disease bronchopulmonary dysplasia. New England J Med. 1967;276:357-68.

Jobe AH, Bancalari E. Bronchopulmonary dysplasia. Am J Respiratory Critical Care Med. 2001;163:1723-9.

Rojas MA, Gonzalez A, Bancalari E, Claure N, Poole C, Neto G. Changing trends in the epidemiology and pathogenesis of neonatal chronic lung disease. J Pedia. 1995;126:605-10.

Smith VC, Zupancic JA, Cormick MC, Croen LA, Greene J, Escobar GJ, et al. Trends in severe bronchopulmonary dysplasia rates between 1994 and 2002. J Pedia. 2005;146:469-73.

Pearson E, Bose C, Snidow T, Ransom L, Young T, Bose G, et al. Trial of vitamin A supplementation in very low birth weight infants at risk for bronchopulmonary dysplasia. J Pedia. 1992;121:420-7.

Bieri JG, Tolliver TJ, Catignani GL. Simultaneous determination of alpha-tocopherol and retinol in plasma or red cells by high pressure liquid chromatography. Am J Clin Nutr. 1979;32:2143-9.

Underwood BA. Biochemical and histological methodologies for assessing vitamin A status in human populations. Methods Enzymol. 1990;190:242-51.

Humphrey JH, Ichord RN. Safety of vitamin A supplementation of postpartum women and young children. Food Nutrition Bulletin. 2001;22:311-19.

Tyson JE, Wright LL, Oh W, Kennedy KA, Mele L, Ehrenkranz RA, et al. Vitamin A supplementation for extremely-low-birth-weight infants. National institute of child health and human development neonatal research network. N Engl J Med. 1999;340:1962-8. Pedia Neo. 2014;55(5):358-62.

Uberos J, Miras MB, Calero AJ, Pez NO. Effectiveness of Vitamin A in prevention of complications of prematurity.

Bancalari E, Claure N. The evidence for non-invasive ventilation in the preterm infant. Arch Dis Child Fetal Neonatal Ed. 2013;98:98-102.

Claure N, Bancalari E. Mechanical ventilatory support in pre-term infants. Minerva Pediatr. 2008;60:177-82.

ESPGHAN committee on nutrition, Aggett PJ, Agostoni C, Axelsson I, De Curtis M, Goulet O, et al. Feeding preterm infants after hospital discharge: a commentary by the ESPGHAN Committee on Nutrition. J Pediatr Gastroenterol Nutr. 2006;42:596-603.

Ambalavanan N, Wu TJ, Tyson JE, Kennedy KA, Roane C, Carlo WA. A comparison of three vitamin A dosing regimens in extremely-low-birth-weight infants. J Pedia. 2003;142:656-61.

Gadhia MM, Cutter GR, Abman SH, Kinsella JP. Effects of early inhaled nitric oxide therapy and vitamin A supplementation on the risk for bronchopulmonary dysplasia in premature newborns with respiratory failure. J Pedia. 2014;164:744-8.