Thrombocytopenia in children: a clinico-etiological profile in an urban tertiary care hospital
DOI:
https://doi.org/10.18203/2349-3291.ijcp20185195Keywords:
Bleeding manifestations, Platelet transfusion, Thrombocytopenia, Viral feverAbstract
Background: Thrombocytopenia is a common haematological finding that we come across while managing a sick child. Etiological profile and presentation of thrombocytopenia varies among children. The objective of this study was to study the clinical and laboratory profile of children with thrombocytopenia, associated clinical complications and assess the relationship between platelet levels and severity of disease.
Methods: The study was carried out in 644 children between 1 month and 12 years, admitted in Paediatric Department of Raja Rajeshwari medical college and hospital, Bangalore between August 2012 to August 2014.
Results: The commonest causes of thrombocytopenia in our study were of infectious aetiology (86.6%). Among Infections Viral infections were the major cause in more than 78% of cases. Other causes included haematological problems, drug induced thrombocytopenia and connective tissue disorders. Bleeding manifestations were present in 33.07% of patients and the commonest bleeds were skin and mucous membranes. Bleeding manifestations were seen most commonly in children with a platelet count less than 50000/µl.
Conclusions: Viral Infections were the commonest cause for thrombocytopenia in Children. Platelet count was neither predictive of bleeding manifestations nor predictive of need for platelet transfusion.
References
References :
Gandhi AA, Akholkar PJ. Clinical and laboratory evaluation of patients with febrile thrombocytopenia. Natl J Med Res. 2015;5(1):43-46.
Suresh P, Devi CY, Ramesh Kumar C, Jalaja Y. Evaluation of the cause in fever with thrombocytopenia cases. J Evidence Based Med Hlthcare. 2015;2(15):2134-7.
Nagler M, Keller P, Siegrist D, Alberio L. A case of EDTA dependent pseudo-thrombocytopenia: simple recognition of under diagnosed and misleading phenomenon. BMC Clin Pathol. 2014;14:19
Nair BT, Sharma K, Paimode SD. A study of clinical and laboratory profile of febrile children presenting with thrombocytopenia. Int J Contemp Pediatr 2017;4:2114-9
Nair PS, Jain A, Khanduri U, Kumar V. A study of fever associated with thrombocytopenia. JAPI. 2003;1151-73
Kumaran C. Incidence (prevalence) and causes of thrombocytopenia at a tertiary health care cen-tre, Oxford Medical College Hospital, Attibele, Anekal, rural part of Bangalore. J Evid Based Med Healthc. 2016;3(32):1516-21
Kumaran C. Incidence (prevalence) and causes of thrombocytopenia at a tertiary health care cen-tre, Oxford Medical College Hospital, Attibele, Anekal, rural part of Bangalore. J Evid Based Med Healthc. 2016;3(32):1516-21
Lakum N, Makwana H, Shah R. A study of laboratory profile of fever with thrombocytopenia in adult patients at C.U. Shah Medical College, Surendranagar. SEAJCRR. 2014;3(1):556- 61.
. Bhalara SK, Shah S, Goswami H, Gonsai RN. Clinical and etiological profile of thrombocytopenia in adults: a tertiary-care hospital-based crosssectional study: Int J Med Sci Public Health. 2015;4:7-10.
Khan AH, Hayat AS, Masood N, Solangi NM, Shaikh TZ. Frequency and clinical presentation of dengue fever at tertiary care hospital of Hyderabad/Jamshoro. JLUMHS. 2010;9:88-94.
Patil P, Solanke P, Harshe G. To study clinical evaluation and outcome of patients with febrile thrombocytopenia. Int J Sci Res Publications. 2014;4(10):01-03.
Lohitashwa SB, Vishwanath BM, Srinivas G. A Study of Clinical and Lab Profile of Fever with Thrombocytopenia. JAPI. 2009:57.
