Importance of vaccines in children with Down syndrome

Authors

  • Mohanned Alrahili College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
  • Ali Binyamen Department of Pediatric, King Abdulaziz Hospital, Jeddah, Saudi Arabia
  • Fares Al Otaibi College of Medicine, Ibn Sina National College, Jeddah, Saudi Arabia
  • Abeer Abu Alnour College of Medicine, Ibn Sina National College, Jeddah, Saudi Arabia
  • Majd Alsaadi College of Medicine, Ibn Sina National College, Jeddah, Saudi Arabia
  • Shahad Aloufi Department of Medicine, Western Al-Azizia Health Care Center, Mecca, Saudi Arabia
  • Fatima Al Sadiq College of Medicine, King Khalid University, Abha, Saudi Arabia
  • Wejdan Alzahrani College of Medicine, Batterjee Medical College, Jeddah, Saudi Arabia
  • Moath Aljabri College of Medicine, Almaarefa Colleges, Riyadh, Saudi Arabia
  • Ahmed Alqarni College of Medicine, Medical University of Lublin, Poland

DOI:

https://doi.org/10.18203/2349-3291.ijcp20183503

Keywords:

Children, Down syndrome, Immune system, Infection, Vaccines

Abstract

Down syndrome is the most common chromosomal disorder affecting infants. It is characterized by various morphological features and systemic manifestations. Immune system is one of the main systems affected by trisomy 21, and it dysfunction is the major etiology for the recurrent infections encountered among patients with Down syndrome. Knowledge about immune system defects had made a considerable progress in prevention of infections among those patients, and subsequently decreased the morbidity and mortality among those patients. Many vaccines were recommended to be administered to Down syndrome patients as a means of prophylaxis against potential infections. Therefore, the life expectancy of Down syndrome witnessed a dramatic improvement during the past few decades. The aim of this review article is to discuss the immune system defects in patients with Down syndrome, the types of infections they are prone to, and the vaccines necessary for prophylaxis against these infections.

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Published

2018-08-24

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Section

Review Articles