DOI: http://dx.doi.org/10.18203/2349-3291.ijcp20182946

Relationship between vitamin D deficiency and atopy in children

Kulthum Al Mahdi, Mariyah Albrahim, Fatimah Alkhars, Ola Alkhalifah, Rabab Alaithan, Fatimah Alhajri

Abstract


Along with its role in regulation of calcium metabolism and bone health, vitamin D is essential for immune system integrity. Vitamin D is an essential immunomodulatory vitamin that interact with the immune system in response to foreign antigens. This interaction is mediated by the vitamin D receptors (VDR) expressed on the surface of various immune cells. Vitamin D has an inhibitory effect on synthesis and release of immunoglobulin E and thus is closely related to atopic disorders. Vitamin D deficiency is a risk factor for bronchial asthma, and it increased asthma-related exacerbation. Low vitamin D levels are encountered in patients with allergic rhinitis and increase the severity of the disease. Other allergic conditions such as atopic dermatitis, contact dermatitis, and food allergy were reported to be significantly correlated with vitamin D serum levels. Despite the established correlation between vitamin D and atopic disorders, double-blinded randomized controlled studies are still lacking to approve this relationship and to provide clear guidelines for the recommended supplementary doses of vitamin D to prevent or treat these conditions. This article aims to review the relationship between vitamin D deficiency and atopy in children.


Keywords


Atopy, Children, Pediatric, Vitamin D, Vitamin D deficiency

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References


Adams JS, Hewison M. Update in vitamin D. J Clin Endocrinol Metab. 2010;95(2):471-8.

Christakos S, Ajibade DV, Dhawan P, Fechner AJ, Mady LJ. Vitamin D: Metabolism. Endocrinol Metab Clin North Am. 2010;39(2):243-53.

Scacchetti AT, Cariani E, Manieri G, Vecchi C, Trenti T. Vitamin D, atopy, immunity. Clin Chem Lab Med. 2014;52(6).:e111-3.

Bikle DD. Vitamin D metabolism, mechanism of action, and clinical applications. Chem Biol. 2014;21(3):319-329.

Bikle DD. Vitamin D and bone. Curr Osteoporos Rep. 2012;10(2):151-9.

Landry CS, Ruppe MD, Grubbs EG. Vitamin D receptors and parathyroid glands. Endocr Pr. 2011;17 Suppl 1:63-68.

del Rosso JQ, Kim GK. The rationale behind topical vitamin D analogs in the treatment of psoriasis where does topical calcitriol fit in? J Clin Aesthet Dermatol. 2010;3(8).

Vuolo L, Di Somma C, Faggiano A, Colao A. Vitamin D and cancer. Front Endocrinol (Lausanne). 2012;3:58.

Wimalawansa SJ. Associations of vitamin D with insulin resistance, obesity, type 2 diabetes, and metabolic syndrome. J Steroid Biochem Mol Biol. 2016.

Beveridge LA, Witham MD. Vitamin D and the cardiovascular system. Osteoporos Int. 2013;24(8):2167-80.

Hewison M. An update on vitamin D and human immunity. Clin Endocrinol (Oxf). 2012;76(3):315-5.

Sahota O. Understanding vitamin D deficiency. Age Ageing. 2014;43(5):589-91.

Balasubramanian S, Ganesh R. Vitamin D deficiency in exclusively breast-fed infants. Indian J Med Res. 2008;127(3):250-5.

Thacher TD, Clarke BL. Vitamin D Insufficiency. Mayo Clin Proc Mayo Clin Proc. 2011;8686(11):50-6050.

Berry JL, Davies M, Mee AP. Vitamin D Metabolism, Rickets, and Osteomalacia. Semin Musculoskelet Radiol. 2002;6(3):173-82.

Whyte MP, Thakker R V. Rickets and osteomalacia. Med (United Kingdom). 2013;41(10):594-9.

Rosen CJ. Clinical practice. Vitamin D insufficiency. N Engl J Med. 2011;364(3):248-54.

Weaver CM. Vitamin D, calcium homeostasis, and skeleton accretion in children. J Bone Mineral Res. 2007 Dec;22(S2):V45-9.

Jutel M, Akdis CA. T-cell subset regulation in atopy. Curr Allergy Asthma Rep. 2011;11(2):139-45.

Abdul G. Hypersensitivity reactions. Med Microbiol J. 2002:19-20.

Wjst M. The vitamin D slant on allergy. Pediatr Allergy Immunol. 2006;17(7):477-83.

Searing DA, Leung DYM. Vitamin D in atopic dermatitis, asthma and allergic diseases. Immunol Allergy Clin North Am. 2010;30(3):397-409.

Bacharier LB. Vitamin D status at birth: An important and potentially modifiable determinant of atopic disease in childhood? J Allergy Clin Immunol. 2014;133(1):154-5.

Lucas RM, Gorman S, Geldenhuys S, Hart PH. Vitamin D and immunity. F1000prime reports. 2014;6.

Miller J, Gallo RL. Vitamin D and innate immunity. Dermatol Ther. 2010;23(1):13-22.

Agmon-Levin N, Theodor E, Segal RM, Shoenfeld Y. Vitamin D in systemic and organ-specific autoimmune diseases. Clin Rev Allergy Immunol. 2013;45(2):256-66.

Stein EM, Shane E. Vitamin D in organ transplantation. Osteoporos Int. 2011;22(7):2107-18.

Theoharides TC. Vitamin D and Atopy. Clin Ther. 2017;39(5):880-3.

Samochocki Z, Bogaczewicz J, Jeziorkowska R, et al. Vitamin D effects in atopic dermatitis. J Am Acad Dermatol. 2013;69(2):238-44.

Vestita M, Filoni A, Congedo M, Foti C, Bonamonte D. Vitamin D and atopic dermatitis in childhood. J Immunol Res. 2015;2015.

Gale CR, Robinson SM, Harvey NC, et al. Maternal vitamin D status during pregnancy and child outcomes. Eur J Clin Nutr. 2008;62(1):68-77.

Brown SD, Calvert HH, Fitzpatrick AM. Vitamin D and asthma. Dermato Endocrinol. 2012;4(2):137-45.

Bozzetto S, Carraro S, Giordano G, Boner A, Baraldi E. Asthma, allergy and respiratory infections: The vitamin D hypothesis. Allergy Eur J Allergy Clin Immunol. 2012;67(1):10-7.

Gupta A, Bush A, Hawrylowicz C, Saglani S. Vitamin D and Asthma in Children. Paediatr Respir Rev. 2012;13(4):236-43.

Brehm JM, Celedón JC, Soto-Quiros ME, et al. 3 Serum vitamin D levels and markers of severity of childhood asthma in Costa Rica. Am J Respir Crit Care Med. 2009;179:765-771.

Arshi S, Ghalehbaghi B, Kamrava S-K, Aminlou M. Vitamin D serum levels in allergic rhinitis: any difference from normal population? Asia Pac Allergy. 2012;2(1):45-8.

Kim YH, Kim KW, Kim MJ, Sol IS, Yoon SH, Ahn HS, et al. Vitamin D levels in allergic rhinitis: a systematic review and meta-analysis. Pediatr Allergy Immunol. 2016;27(6):580-90.

Suaini NHA, Zhang Y, Vuillermin PJ, Allen KJ, Harrison LC. Immune modulation by vitamin D and its relevance to food allergy. Nutrients. 2015;7(8):6088-108.