Prospective study of clinical profile, causes, risk factors and treatment of hyperbilirubinemia in preterm and term babies

Authors

  • Komal Garg Department of Paediatrics, Kamineni Institute of Medical Sciences, Narketpally, Telangana, India
  • Vamshi Krishna Kondle Department of Paediatrics, Kamineni Institute of Medical Sciences, Narketpally, Telangana, India

DOI:

https://doi.org/10.18203/2349-3291.ijcp20183519

Keywords:

Hyperbilirubinemia, preterm babies, term babies

Abstract

Background: Neonatal jaundice is often physiologic and benign, but dangerous, at levels producing neurological injury, adding on to mortality and morbidity in developing nations. Hence the present study is undertaken to document the proportion, clinical profile, causes, risk factors and treatment of hyperbilirubinemia in preterm and term babies.

Methods: This study conducted over 100 hyperbilirubinemia babies who admitted in Rich Pediatric Hospital, Pogathota, Nellore during the period of October 2014 to September 2015.Hyperbilirubinemia is more common among preterm babies born to mothers of 19-22 years and term babies born to mothers of 21-26 years age group.

Results: The most common etiological factors identified among all the gestational categories were sepsis (23.0%) followed by ABO incompatibility (20.0%) and Rh incompatibility (6.0%). Among preterm babies (35-37 wks.) the most common were ABO incompatibility (15.0%), Sepsis (10.0%) and polycythemia (10.0%), while among term babies, the most common factors were ABO incompatibility (23.9%), Sepsis (16.4%) Rh incompatibility (7.5%) and Cephalhaematoma (7.5%). In a large proportion of cases, etioliogy remined idiopathic (44.0%).

Conclusions: Requirement of exchange transfusion was more among term babies compared to preterm babies. Rh incompatibility was the only etiology.

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References

Camilia R. Martin, Mary Lucia P. Gregory, John P. Cloherty. Neonatal Hyperbilirubinemia. Manual of Neonatal Care. 7th ed. Cloherty JP, Eichenwald EC, Hansen AR, Stark AR: Lippincott Williams and Wilkins; 2012:304-39.

Sgro M, Campbell D, Shah V. Incidence and cases of severe neonatal hyperbilirubinemia in Canada. CMAJ. 2006;175(6):587-90.

Maisels MJ, Watchko JF, Bhutani VK, Stevenson DK.An approach to the management of hyperbilirubinemia in the preterm infant less than 35 weeks of gestation. J Perinatol. 2012;32:660-4.

Narang A, Kumar P, Kumar R, Neonatal Jaundice in very low birth Weight babies. Indian J Pediatr. 2001;68(4):307-10.

KJ Barrington, K Sankaran, Canadian Pediatric Society, Fetus and Newborn committee, Guidelines for detection, management and prevention of hyperbilirubinemia in late preterm and term newborns, Pediatric Child Health. 2012;12(SB):1B-12B.

Sarici SU, Serdar MA, Korkmaz A, Erdem G, Oran O, Tekinalp G, Yurdakok M, Yigit S. Incidence, course and prediction of hyperbilirubinemia in near-term and term newborns. Pediatr. 2004;113(4):775-80.

Arif K, Bhutta ZA. Risk factors and spectrum of neonatal jaundice in a birth cohort in Karachi. Indian Pediat. 1999;36(5):487.

Gale R, Sediman Ds, Dollberg S, Stevenson DK. Epidemiology of neonatal jaundice in the Jerusalem population. J Pediatr Gastroenterol Nutr. 1990;10(1):82-6.

Cheng SW, Chiu YW, Weng YH. Etiological analyses of marked neonatal hyperbilirubinemia in a single institution in Taiwan. Chang Gung Med J. 2012;35(2):148-54.

Bertini G, Dani C, Tronchin M, Rubaltelli FF. Is breastfeeding really favoring early neonatal jaundice? Pediatr. 2001;107(3):E41.

Singhal PK, Singh M, Paul VK, Deorari AK, Ghorpade MG. Spectrum of neonatal hyperbilirubinemia: an analysis of 454 cases. Indian Pediatr. 1992;29(3):319-25.

Narang A, Gathwala G, Kumar P. Neonatal jaundice-an analysis of 551 cases. Indian Pediatr 1997;34:429-32.

Siyah Bilgin B, Altun Koroglu O, Yalaz M, Karaman S, Kultursay N. Factors affecting bilirubin levels during first 48 hours of life in healthy infants. BioMed Res Int. 2013;2013.

Kulkarni SK, Dolas AL, Doibale MK. Profile and causes of neonates with indirect hyperbilirubinemia in a tertiary care centre. Int J Basic Appl Med Sci. 2013;3:110-5.

Bhat. S. Neonatal Jaundice. Guha’s Neonatology Principales and practice 3rd ed. Saili. A, Bhat S, Shenoi. A: Jaypee publishers. 2005;879-900.

Madan A, MacMohan JR, Stevenson DK. Neonatal hyperbilirubinemia: Textbook of the newborn 5th ed. A very GB, Fletcher MA, Mac Donald MG: Lippincott Willian and Willian. 1999;1226-56.

Seddighah Sakha, Manizha Mostafa et al Exchange Transfusion in severe hyperbilirubinemia an experience in North West Iran Turkish, Journal Paediat. 2010;52(4):367-71.

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Published

2018-08-24

How to Cite

Garg, K., & Kondle, V. K. (2018). Prospective study of clinical profile, causes, risk factors and treatment of hyperbilirubinemia in preterm and term babies. International Journal of Contemporary Pediatrics, 5(5), 1851–1858. https://doi.org/10.18203/2349-3291.ijcp20183519

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Original Research Articles