A study of morbidity and mortality profile among preterms suffering from Hyaline Membrane Disease in a tertiary care hospital in Cuttack, India

Mounesh Pattar, Leena Das


Background: Every newborn carries within itself immense possibility to transform into a complete healthy human being and fulfill the needs the future will demand. Of the problems of premature baby, respiratory causes are the commonest admission to NICU. The common respiratory problem encountered is Respiratory distress syndrome (RDS) also known as Hyaline membrane disease (HMD), whose incidence increases as babies are born early. The objective of the study was to assess the morbidity and mortality profile among preterms suffering from Hayaline membrane disease in a tertiary care hospital in Cuttack.

Methods: A prospective comparative study was conducted in the neonatal intensive care unit of SVPPGIP Hospital attached to the SCB Medical College, Department of Pediatrics, Cuttack from September 2010 to September 2012. A total of 103 preterm newborn with Hyaline membrane disease were included in the study.

Results: Out of 103, 67 male and 36 females were included in the study.

The total neonatal death in our study was 44 (42.7%) pre-term out of 103 subjects. The death of neonate within 1st week or 168 hrs of age of birth irrespective of cause was considered for early neonatal death which was 21 (47.7%) of the total neonatal death.

Conclusions: It may be worth considering surfactant replacement therapy in neonates between with RDS 30-33 weeks gestation in level III care setup in our country even being referred late but less than 24 hrs of age with supportive and aseptic care.


Mortality, Morbidity, Preterm, RDS, Surfactant

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Park K: Park‘s Textbook of Preventive and Social Medicine, 24th edition. M/s Banarsidas. Bhanot Publishers, Jabalpur, India. 2017.

Rubaltelli FF, Dani C, Reali MF. Acute neonatal respiratory distress in Italy:aone-year prospective study. Acta Paediatr. 1998;87:1261-8.

Graig JJ. Respiratory Distress Syndrome In The Preterm Infant: In Gleason CA, Devaskar SU. Avery’s text book of the newborn, 9th ed, Philadelphia, Elsevier;2012:633-646.

Carlo WA. High risk infant. In klingman, Stanton, st game, schor at al editors: Nelson text of Pediatric, 19th ed, Philadelphia. Elsevier;2011:552-564.

Greenough, Milner AD, Robertson NRC Neonatal respiratory disorders. 1996. Edward Arnold, London.

Soll RF, Blanco F. Natural surfactant extract versus synthetic surfactant for neonatal respiratory distress syndrome. Cochrane Database Syst Rev. 2001;1(2).

Rubaltelli FF, Dani C, Reali MF, Bertini G, Wiechmann L, Tangucci M, et al. Italian Group of Neonatal Pneumology. Acute neonatal respiratory distress in Italy: a one‐year prospective study. Acta Paediatrica. 1998;87(12):1261-8.

NNPD network.Morbidity and mortality profile of outborn babies in 14 tertiary care centrers in indiain 2002.abstract-XXIII annual convention of national neonatalogy forum of india.2003;133-34.

NNF of india. National neonatal perinatal Database- Report for 2003.Available at

Soll RF, Morley CJ. Prophylactic versus selective use of surfactant in preventing morbidity and mortality in preterm infants. Cochrane Database Syst Rev. 2001;2(2).

Bhutta ZA, Yusuf K.Neonatal respiratory distress syndrome in Karachi: some epidemiological considerations. Paediatr Perinat Epidemiol. 1997;11(1):37-43.

Narang A, Kumar P, Dutta S, Kumar R. Surfactant therapy for hyaline membrane disease: The Chandigarh experience. Indian Pediatr. 2001;38(6): 640-6.

Femitha P, Rojo Joy, Adhisivam B, Prasad K, Bahubali D Gane, et al. Surfactant REPLACEMENT Therapy (SRT) in respiratory distress syndrome (RDS). Curr Pediatr Res. 2012;16(2):134-36.

Bae YM, Bae CW. The changes in the mortality rates of low birth weight infant and very low birth weight infant in Korea over the past 40 years. J Korean Med Sci. 2004;19(1):27-31.

Bhakoo ON. Assisted ventilation in neonates: The Indian perspective. Indian Pediatr 1995;32:1261-4.

Bae CW. The changes in the birth and mortality rates of newborn in Korea. J Korean Med Assoc. 2006;49(11):975-82.

Jobe AH. Pulmonary surfactant therapy. N Engl J Med. 1993;328:861-8.