Stenotrophomonas maltophilia: a rare cause of early onset neonatal sepsis

Chapay Soren, Snigdha Jagtap, V. Malathi, Lakshmi Aparnadevi V. V.


Stenotrophomonas maltophilia is a rare cause of early onset neonatal sepsis. The extensive resistance of this organism to several antibiotics leaves fewer options for antimicrobial therapy. A few cases were reported in neonates. We present a case of early onset sepsis in a neonate caused by Stenotrophomonas maltophilia. The newborn was born preterm and presented with respiratory distress within two hours of birth. Stenotrophomonas maltophilia is a rare cause early onset neonatal sepsis with significant morbidity and mortality.


Stenotrophomonas maltophilia, neonatal sepsis

Full Text:



Denton M, Kerr KG. Microbiological and clinical aspects of infection associated with Stenotrophomonas maltophilia. Clin Microbiol Rev. 1998;11:57-80

Brooke JS. Stenotrophomonas maltophilia: an emerging global opportunistic pathogen. Clin Microbiol Rev. 2012;25:2-41.

Guyot A, Turton JF, Garner D. Outbreak of Stenotrophomonas maltophilia on an intensive care unit. J Hosp Infect. 2013;85(4):303-7.

Alfieri N, Ramotar K, Armstrong P. Two consecutive outbreaks of Stenotrophomonas maltophilia (Xanthomonas maltophilia) in an intensive-care unit defined by restriction fragment-length polymorphism typing. Infect Control Hosp Epidemiol. 1999;20(8):553-6.

Çetin BS, Çelebi S, Özkan H. Stenotrophomonas maltophilia outbreak in neonatal intensive care unit and outbreak management. J Pediatr Infect. 2015;9:147.

Giligan P, Lum G, Vandamme PAR, Burkholderia WS. Stenotrophomonas, Ralstonia, Brevundim Comamonas, Delftia, Pandoraea, and Acidovorax. In: Manual of Clinical Microbiology. 8th ed. Murray PR (Ed), ASM, Washington; 2003;729-748.

Looney WJ, Narita M, Mühlemann K. Stenotrophomonas maltophilia: an emerging opportunist human pathogen. Lancet Infect Dis. 2009;9:312.

Sarvamangala-Devi JN, Venkatesh A, Shivanandra PG. Neonatal infections due to Pseudomonas maltophilia. Indian Pediatr. 1984;20:72-3.

Basu S, Das P, Roy S, De S, Singh A. Survey of gut colonization with Stenotrophomonas maltophilia among neonates. J Hosp Inf. 2009;72:183-5.

Chang YT, Lin CY, Chen YH, Hsueh PR. Update on infections caused by Stenotrophomonas maltophilia with particular attention to resistance mechanisms and therapeutic options. Front Microbiol. 2015;6:893.

Viswanathan R, Singh AK, Ghosh C, Basu S. Stenotrophomonas maltophilia causing early onset neonatal sepsis. Indian Pediatrics. 2011;48(5):397-9.

Verweij PE, Meis JF, Christmann V, Van er Bor M, Melchers WJ, Hilde Rink BG, et al. Nosocomial outbreak of colonization and infection with Stenotrophomonas maltophilia in preterm infants associated with contaminated tap water. Epidemiol Infect. 1998;120:251.

Aygun AD, Akarsu S, Kilic M, Ozdiler S, Toprakil I. Purpura fulminans due to Stenotrophomonas maltophilia infction in a premature infant. Pediatr Int. 2006;48:346-8.