DOI: http://dx.doi.org/10.18203/2349-3291.ijcp20182078

Assessment of health-related quality of life in paediatric asthma patients

Noushadali A. K., Uma Mohandas, Thaha Hussain

Abstract


Background: Bronchial Asthma is one of the important chronic disease in children. This disease can affect the children mentally and physically in various aspects. Health related quality of life (HRQoL) has become an increasing important issue in the management of Asthma and it is how often used to evaluate the effectiveness of antiasthma drugs. The objectives of the study are to assess the health-related quality of life in Pediatric patients by using Pediatric Asthma quality of life questionnaire and also to assess the impact of parent education in health-related quality life of Asthma patient. The other intention of the study is to determine the anti-asthma drugs utilisation pattern in Pediatric patients.

Methods: This study was conducted in in-patient and out-patient department of tertiary care Hospital for a period of 1 year. 145 pediatric patients were participated in this study. A comparative study was conducted to describe the HRQoL in asthma and the pediatric asthma quality of life questionnaire is used to determine the HRQoL of the subjects. Statistical analysis was performed using the instant prism ANOVA test and the Bartlett’s test. P <0.05 was considered statistically significant.

Results: This study shows that asthma is more common in male compared to female and most common type was Mild Persistent (47.85). Most of the patient are treated with bronchodilator (71%) followed by steroid (49%) and Leukotrien Antagonist (30.43%). Also revealed that most of the patients are taking multiple drug therapy compared to mono therapy. Quality of life having significant difference in all domains by comparing first visits score. Those suffering from the intermittent type of asthma showed higher mean quality of life score in all domains by comparing first visit score vs second visit score vs third visit score.

Conclusions: The health-related quality of life having improvement in all domain and overall quality of life by comparing the initial visit to the follow up visits.  The patient education plays major role in improving the quality of life of pediatric population and the quality of life score having relationship with gender, age educational status, severity of asthma and the drug utilization improving health related quality of life.


Keywords


Bronchial asthma, HRQoL, Intermittent, Mild, Moderate, Severe persistent asthma

Full Text:

PDF

References


Braman SS. The Global Burden of Asthma. Chest 2006;130:4S-S

Agarwal R, Dhooria S, Aggarwal AN, Maturu VN, Sehgal IS, Muthu V et al. Guideline for diagnosis and management of Bronchial asthma. 2015;32:3-4

Juniper EF, Guyatt GH, Epstein RS, Ferric PJ, Jaeschke R, Hiller TK. Evaluation of impairment of health-related quality of life in asthma: developmentof a questionnaire for use in clinical trials. Thorax.1992;47:76-83.

Merikallio VJ, Mustalahti K, Remes ST, Valovirta EJ, Kaila M. Comparison ofquality of life between asthmatic and healthy school children. Pediatr Allergy Immunol. 2005;16:332-40.

Graham DM, Blaiss MS, Bayliss MS, Espindle DM, Ware JE, Jr. Impact of changes in asthma severity on health-related quality of life in pediatric and adult asthma patients: results from the asthma outcomes monitoring system. Allergy Asthma Proc. 2000;21:151-8

Sporik R, Holgate ST, Platts-mills TA, Cogswell JJ. Exposure to house-dust mite allergen (der pi) and the development of asthma in childhood. A prospective study. N Eng J Med. 1990;323:502-7

Silverman RA, Stevenson L, Hastings HM. Age-related seasonal patterns of emergency department visits for acute asthma in an urban environment. Ann Emerg Med. 2003;42:57786.

Rijssenbeek-NLH, Oosting AJ, Bruin WMS, Bregman I, de Monchy JG, Postma DS. Clinical evaluation of the effect of anti-allergic mattress covers inpatients with moderate to severe asthma and house dust mite allergy: a randomized double blind placebo controlled study. Thorax. 2002; 57:784-90

Getahun D, Demissie K, Rhoads GG. Recent Trends in Asthma Hospitalization and Mortality In The United States. J Asth. 2005;42:373-8

Christie MJ, French D, Sowden A, West A. Develpoment of child centred disease-specific questionnaire for with asthma. Psychosom Med.1993;55:541-8

Harju T, Keistinen T, Tuuponen T, Kivela SL. Seasonal variation in childhood asthma hospitalisations in Finland, 1972-1992. Eur J Pediatr. 1997;156:436-9

Roberts G, Hurley C, Lack G. Development of a quality-of-life assessment for the allergic child or teenager with multisystem allergic disease. J Allergy Clin Immunol. 2003;111:49l-7

Fanta CH. Asthma. New Eng J Med. 2009;360:1002-14

Lazarus SC. Clinical Practice. Emergency treatment of asthma. N Eng J Med. 2010;363:755-64.

Anderson HR, Gupta R, Strachan DP, Limb ES. 50 years of asthma: UK trends from 1955 to 2004. Thorax. 2007 Jan 1;62(1):85-90.

Kanter LJ, Siegel CJ, Snyder CF, Pelletier EM, Buchner DA, Goss TF. Impact of respiratory symptoms on health-related quality of life and medical resource utilization of patients treated by allergy specialists and primary care providers. Ann Allergy Asthma Immunol. 2002;89:139-47.

Juniper EF, Guyatt GH, Feeny DH, Griffith LE, Ferric PJ, Minimum skillsrequired by children to complete health related quality of life instruments forasthma: comparison of measurement properties. Eur respire J. 1996;5:27-34

Townsend M, Feeny DH, Guytt GH, Furlong WJ, Seip AE, Dolovich J. Evaluation of the burden of illness for pediatrics asthmatic patients and their parents. Ann allergy. l991;67:403-8

Robert G, Mylonopoulou M, Hurley C, Lack G. Impairment quality of life is directly related to the level of allergen exposure and allergic airway inflammation. Clin Exp Allergy. 2005;35:1295-300

Khot A, Burn R, Evans N, Lenney C, Lenney W. Seasonal variation and time trends in childhood asthma in England and Wales 1975-81. Br Med J (Clin Res Ed).1984;289:235-7.