DOI: http://dx.doi.org/10.18203/2349-3291.ijcp20182557

Correlation of maternal lipid profile with newborn’s lipid profile

Anamika Gora, Deveshwar Dev, Palak Gupta, M. L. Gupta

Abstract


Background: Atherosclerotic cardiovascular disease (CVD) is a major cause for morbidity and mortality in the adult population. Altered lipid levels are the recognized factors. This process is considered to begin in early life and progress silently over decades. Maternal lipid concentrations may exert an in-utero influence on infant’s lipid profile. The objective of the study was to find out the correlation of maternal lipid profile with newborn’s lipid profile.

Methods: This is a hospital based, cross sectional study. After applying inclusion and exclusion criteria, a total of 220 parturients and their respective newborns were enrolled. Out of 220 newborns, 110 were <2.5 kg (group A) and 110 were ≥2.5kg (group B) babies. 2.5 ml of Cord blood sample from each of enrolled newborns was collected from the placental end of the cord just after the delivery. Blood samples from the parturients were collected right after delivery. The concentrations of total cholesterol, triglycerides and HDL-c were determined by an enzymatic colorimetric method and LDL-c was calculated by the Friedewald formula.

Results: In present study there was a statistically significant but poor negative correlation between maternal TG and babies’ TG level among low birth weight (˂2.5kg) babies and no other significant correlation was observed between maternal lipid profile and newborn’s lipid profile.

Conclusions: Change in maternal lipid profile is not significantly associated with the mean concentrations of total cholesterol, LDL-c, HDL-c and triglycerides in newborns. Hence it shows that neonatal lipogenesis may be independent of maternal lipogenesis.


Keywords


HDL-C, LDL-C, Total cholesterol, Triglycerides

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References


Glueck CJ, Heckman F, Schoenfeld M. Neonatal familial type II hyperlipoproteinemia: cord blood cholesterol in 1800 births. Metabolism. 1971;20:597-608.

Andersen GE, Friis-Hansen B. Neonatal hypertriglyceridemia. A new index of ante partum and intrapartum fetal distress. Acta Pediatr Scand. 1976; 65:369-74.

Tsang RC, Glueck CJ, Evans G, Steiner P. Cord blood hypertriglyceridemia. Am J Dis Child. 1974;127:78-82.

Ginsburg BE, Zetterstrom R. Serum cholesterol concentrations in newborn infants with gestational ages of 2842 weeks. Acta Pacdiatr Stand. 1980;69:587-92.

Fosbrooke AS, Wharton BA. Plasma lipids in umbilical cord blood from infants of normal and low birth weight. Biol Neonate. 1973;23:33,338.

Carr BR, Parker JR CR, Milewich L, Porter JC, Macdonald PC, Simpson ER. The role of low-density, high-density, and very low-density lipoproteins in steroidogenesis by the human fetal adrenal gland. Endocrinology. 1980;106:185,1860.

Parker CR, Simpson ER, Bilheimer DW, Leveno K, Carr BR, MacDonald PC. Inverse relation between low-density lipoprotein-cholesterol and dehydroisoandrosterone sulfate in human fetal plasma. Science. 1980;208:512-4.

Buster JE. Fetal adrenal cortex. Clin Obstet Gynecol. 1980;23:803-24.

Parker Jr CR, Carr BR, Simpson ER, MacDonald PC. Decline in the concentration of low-density lipoprotein-cholesterol in human fetal plasma near term. Metabolism. 1983;32:919-23.

Ghiasi A, Ziaei S, Faghihzadeh S. The relationship between levels of lipids and lipoprotein B-100 in maternal serum and umbilical cord serum and assessing their effects on newborn infants anthropometric indices. J Midwifery Reprod Health. 2014;2(4):227-36.

Choo KE, Davis TM, Mansur MA, Azman E, Achana S. Serum lipid profiles in Malay mothers and neonates: A cross-sectional study. J Paediatr Child Health. 1996;32(5):428-32.

Ortega R, Gaspar M, Cantero M. Influence of maternal serum lipids and maternal diet during the third trimester of pregnancy on umbilical cord blood lipids in two populations of Spanish newborns. Int J Vitamin Nutr Res. 1995;66(3):250-7.

Knopp RH, Bonet B, Zhu X. Lipid metabolism in pregnancy. In: Cowett RM, ed. Principles of perinatal-neonatal metabolism. 2nd ed. New York: Springer; 1998:221-58.