Clinical profile of patients with steroid sensitive nephrotic syndrome at tertiary care centre in Gujarat, India


  • Nimisha K. Pandya Department of Pediatrics, GMERS Medical College, Gotri, Vadodara, Gujarat, India
  • Kedar G. Mehta Department of Preventive and Social Medicine, GMERS Medical College, Gotri, Vadodara, Gujarat, India



Complications, Nephrotic syndrome, Steroid sensitive


Background: Nephrotic syndrome is a significant cause of chronic renal disease in children. The objective of the study was to analyze demographic profile, response to steroids and associated complications, in children with Nephrotic syndrome.

Methods: A retrospective study of all patients referred to Renal diseases clinic at GMERS Medical College Gotri Vadodara was done. Period of study was from year 2014 to June 2017. Variables assessed were sex distribution, age at presentation for first attack, occurrence of complications, steroid responsiveness and use of steroid sparing agents. Study was done from special clinic cards used for documentation of visits of patients in Nephrotic disease special clinic.

Results: 59 patients were studied. Mean age at presentation of was 4.08 years. Sex distribution ratio was 1.18:1. 88% of cases were infrequent relapsers. Steroid dependence was observed in 8.4% of cases. Complications were noted in 38% children. UTI was the commonest complication 13.5%. Associated renal conditions were present in 5% of children.

Conclusions: In the present study clinical profile of children with Nephrotic syndrome was concordant with typical nephrotic syndrome in children. Pattern of nephrotic syndrome and response to treatment did not differ significantly from other studies.


Eddy AA, Symons JM. Nephrotic Syndrome in childhood. Lancet. 2003;362(9384):629-39.

Ali U, Bagga A, Banerjee S, Kanitkar M, Phadke KD, Senguttuvan P, et al. Revised guidelines for management of steroid-sensitive nephrotic syndrome. Indian Pediatr. 2008;45:203-14.

Gulati S, Kher V, Gulati K, Arora P, Gujral R. Tuberculosis in childhood nephrotic syndrome in India. Pediatr Nephrol. 1997;11:695-8.

Gorensek MJ, Lebel MH, Nelson JD. Peritonitis in children with nephrotic syndrome. Pediatr. 1988;81:849-56.

Alwadhi RK, Mathew JL, Rath B. Clinical profile of children with nephrotic syndrome not on glucorticoid therapy but presenting with infection. J Paediatr Child Health. 2004;40:28-32.

Anderson DC, York TL, Rose G, Smith CW. Assessment of serum factor B, serum opsonins, granulocyte chemotaxis, and infection in nephrotic syndrome of children. J Infect Dis. 1979;140:1-11.

Shah RC, Shah NK, Kukreja S. Pneumococcal vaccines. In: Shah RC, Shah NK, Kukreja S, editors. IAP Guide Book on Immunization. Mumbai: Wyeth; 2007:35-6.

Grenda R, Webb NJ. Steroid minimization in pediatric renal transplantation: early withdrawal or avoidance? Pediatr Transplant. 2010;14:961-7.

Sahana KS. Clinical Profile of nephrotic syndrome in children. J Evol Med Dent Sci. 2014;3(4):863-70.

Simpson AK, Wong W, Morris MC. Pediatric nephrotic syndrome in Auckland, New Zealand. J Paediatr Child Health. 1998;34(4):360-2.

Safaei A, Maleknajed S. Spectrum of childhood nephrotic syndrome in Iran: a single centre study. Indian J Nephrol. 2009:19(3):87-90.






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