Role of human milk fortifier on weight gain in very low birth weight babies

Authors

  • Ganesh K. Verma Department of Pediatrics, UPUMS Saifai, Etawah, Uttar Pradesh, India
  • Amitesh Yadav Department of Pediatrics, GSVM Medical College, Kanpur, Uttar Pradesh, India

DOI:

https://doi.org/10.18203/2349-3291.ijcp20180479

Keywords:

HMF, Fortification, VLBW

Abstract

Background: Poor weight gain and postnatal growth of VLBW neonates continues to be a major problem. Breast feeding with HMF fortification show positive effect on growth. Main objective is to study the weight gain pattern in very low birth weight babies supplemented with HMF.

Methods: This is an observational study conducted in NICU, Department of Pediatrics, U.P. Rural Institute of Medical Sciences and research Saifai, India between January 2015- June 2016 for assessing the weight gain pattern in VLBW neonates supplemented with HMF.

Results: Maximum number of babies supplemented with HMF achieved the targeted weight in 8-14 days (32.2%) followed by those who attained this weight within 15-21 days (30%), 22-28 days (21.1%), <7 days (13.3%) and >28 days (3.3%) respectively. Mean time taken to achieve the targeted weight was 16.69±7.19 days.

Conclusions: We concluded that the supplementation with HMF, can result in a significant increase in growth. We demonstrated that fortification of human milk, with HMF did not cause any measured adverse effects in VLBW neonates. 

References

Hay WW Jr, Lucas A, Heird WC, Ziegler E, Levin E, Grave GD, et al. Workshop summary: nutrition of the extremely low birth weight infant. Pediatrics. 1999;104:1360.

Schanler RJ, Garza C, Nichols BL. Fortified mothers' milk for very low birth weight infants: results of growth and nutrient balance studies. J Pediatr. 1985;107:437.

Butte NF, Garza C, Smith EO, Nichols BL. Human milk intake and growth in exclusively breast-fed infants. J Pediatr. 1984;104:187.

Section on Breastfeeding. Breastfeeding and the use of human milk. Pediatrics. 2012;129:e827.

Morley R, Lucas A. Randomized diet in the neonatal period and growth performance until 7.5-8 y of age in preterm children. Am J clin Nutr. 2000;71:822-8.

National Neonatology Forum India. Evidence based clinical practice guidelines: NNF; 2011:11-20. Available at http://babathakranwala.in/IAP-neo-chap/uploads/acd-corner/nnf_guidelines-2011.pdf

Stocks J. Effect of nasogastric tubes on nasal resistance during infancy. Arch Dis Child. 1980;55:17-21.

Bhandari N, Taneja S, Rongsen T, Chetia J, Sharma P, Bahl R et al. Implementation of the WHO Multicentre Growth Reference Study in India. Food Nutr Bull. 2004 Mar;25(1 Suppl):S66-71.

Marfell-Jones M, Olds T, Stewart A, Carter L. International standards for anthropometric assessment: International Society for the Advancement of Kinanthropometry: Potchefstroom, South Africa. 2006. Available at http://www.ceap.br/material/MAT17032011184632.pdf

World Health Organization. Training Course on Child Growth Assessment. Module B “Measuring a Child’s Growth. Geneva, WHO, 2008. Available at http://www.who.int/childgrowth/training/en/ Accessed on 10th June 2012.

Kuschel CA, Harding JE. Multicomponent fortified human milk for promoting growth in preterm infants', Cochrane Database Syst Rev. 2004;1:CD000343.

Lucas A, Fewtrell MS, Morley R, Lucas PJ, Baker BA, Lister G, et al. Randomized outcome trial of human milk fortification and developmental outcome inpreterm infants. Am J Clin Nutr. 1996;64:142-51.

Metcalf R, Dilena B, Gibson R, Marshall P, Simmer K. How appropriate are commercially available human milk fortifiers?'. J Pediatr Child Health. 1994;30(4):350-5.

Ziegler EE. Breast-milk fortification. Acta Paediatr. 2001;90:720-3.

Martins EC, Krebs VLJ. Effects of the use of fortified raw maternal milk on very low birth weight infants. J Pediatr (Rio J). 2009;85(2):157-62.

Mukhopadhyay K, Narang A, Mahajan R. Effect of human milk fortification in appropriate for gestation and small for gestation preterm babies: a randomized controlled trial. Indian Pediatr. 2007 Apr 1;44(4):286.

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Published

2018-02-22

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Original Research Articles