Prevalence and predictors for lipodystrophy syndrome among HIV infected children on anti-retroviral therapy


  • Anirban Mandal Department of Pediatrics, All India Institute of Medical Sciences, New Delhi
  • Amitabh Singh Chacha Nehru Bal Chikitsalaya, New Delhi



Lipodystrophy syndrome, Anti-retroviral therapy


First of all, the efforts made by the authors in trying to find out the prevalence and more importantly the predictors of lipodystrophy syndrome in HIV infected children on anti-retroviral therapy is much appreciated.1 But, the study was undertaken with the patients mostly (72%) on stavudine based therapy which is not currently being used as first line therapy in adolescents and adults due to many long-term toxicities including lipodystrophy.2 The strong association is also very evident in the present article and makes the finds of high prevalence of these metabolic abnormalities predictable. Clinical method applied for assessing “fat redistribution” encompassed both ‘lipo-atrophy’ and ‘lipo-hypertrophy’. Therefore, the high prevalence of fat redistribution (39.8%) may be due to the wasting present in these children secondary to their malnutrition which would contribute to ‘lipo-atrophy’ and thus fat redistribution.


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