DOI: http://dx.doi.org/10.18203/2349-3291.ijcp20180030

Spectrum of congenital anomalies of neonates in a tertiary care hospital in Southern India

Ananya S. L. Tenali, Santosh K. Kamalakannan, Kumutha K. Jayaraman

Abstract


Background: Congenital anomalies contribute upto 11% of neonatal deaths globally. Neonates with multiple congenital malformations present a very difficult challenge to the treating physicians. This study was done to know the frequency, pattern of congenital anomalies and various presentations, which may help to develop strategies for patient counseling and management in our setting.

Methods: Retrospective hospital based observational study from the period of June 2015 to June 2017. Neonates born in our hospital during the study period with documented congenital anomalies were included in the study and the data was classified as per European Surveillance of Congenital Anomalies and further analysed.

Results: Total number of neonates with documented congenital anomalies was 40, of which 6 neonates (15%) had multiple anomalies. The anomalies in the study were divided into major and minor anomaly groups. 70% of the anomalies were classified as major anomalies while 30% were classified as minor anomalies. Multiparity and GDM were found to be major risk factors in the mother. Major anomalies identified involved the Musculoskeletal system (21.6%) and cardiovascular system (20%). Minor anomalies included skin disorders (27.7%) followed by Musculoskeletal (16.6%) and genitourinary system (16.6%). Of the 40 anomalous babies five babies expired soon after birth

Conclusions: Antenatal screening is an effective tool to detect Musculoskeletal and CNS anomalies. CVS anomalies may be missed by routine anomaly scan. Early intervention and effective follow up have shown that good outcomes are possible even in while managing some of the major anomalies. 


Keywords


Congenital anomalies, EUSCAT classification, Major anomalies, Minor anomalies

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References


World Health Organization. Section on congenital anomalies. Available from: http://www.who.int/mediacentre/factsheets/fs370/en/ Accessed October 2012.

National health Portal of India. Section on congenital anomalies (birth defects). Available at https://www.nhp.gov.in/disease/gynaecology-and-obstertrics/congenital-anomalies-birth-defects

UNICEF. Neonatal Health. Available at Unicef.in/whatwedo/2/Neonatal-Health

Agarwal SS, Singh US, Singh PS, Singh SS, Das VI, Sharma AN, et al. Prevalence and spectrum of congenital malformations in a prospective study at a teaching hospital. Indian J Med Res. 1991;94:413-9.

Patel ZM, Adhia RA. Birth defects surveillance study. Indian J Pediatr. 2005;72:489-91.

Jehangir W, Ali F, Jahangir T, Masood MS. Prevalence of gross congenital malformations at birth in the neonates in a tertiary care hospital. In APMC. 2009;3(1):47-50.

Chaturvedi P, Banerjee KS. Spectrum of congenital malformations in newborns from rural Maharashtra. Indian J Pediatr. 1989;56:501-7.

Bhide P, Gund P, Kar A. Prevalence of congenital anomalies in an Indian maternal cohort: healthcare, prevention, and surveillance implications. PloS One. 2016;11(11):e0166408.

Swain S, Agarwal A, Bhatia BD. Congenital malformations at birth. Indian Paediatr. 1994;31:1187-91.

Bhat BV, Babu L. Congenital malformations at birth: a prospective study from South India. Indian J Pediatr. 1998;65:873-81.

Dolk H, Loane M, Garne E. The prevalence of congenital anomalies in Europe. Advances Exp Med Biol. 2010;686:349-64.

Verma M, Chhatwal J, Singh D. Congenital malformations: a retrospective study of 10,000 cases. Indian J Pediatr. 1991;58(2):245-52.

Datta V, Chaturvedi P. Congenital malformations in rural Maharashtra. Indian Paediatr. 2000;37:998-1001.

Khanna MP, Prasad LS. Congenital malformations in the newborn. Indian J Paediatr. 1967;230:63-71.

Taksande A, Vilhekar K, Chaturvedi P, Jain M. Congenital malformation at birth in central India, Indian J Hum Genetics. 2010;16:159-63.

Anand JS, Javadekar BB, Mala B. Congenital malformations in 2000 consecutive births. Indian Pediatr. 1988;25:845-51.

Charlotte TN, Aurore ND, Charlotte B, Esther B, Eugene BP. Prenatal diagnosis of congenital malformations in Douala General Hospital. Open J Obstet Gynecol. 2015;5(15):839.

Coulibaly-Zerbo F, Amorissani-Folquet M, Kacou-Kakou A, Sylla M, Noua F, Kramo E, et al. Epidemiological study of congenital malformations.

Medicine of Black Africa. 1997;44(7):409-14.

Ajay K, Kalra K, Sharma V, Singh M, Dayal RS. Congenital malformations. Indian Paediatr. 1984;21:945-9.

Sarkar S, Patra C, Dasgupta MK, Nayek K, Karmakar PR. Prevalence of congenital anomalies in neonates and associated risk factors in a tertiary care hospital in Eastern India. J Clin Neonatol. 2013;2(3):131.