Cord blood lipid profile in late preterm and term neonates

Yashodha H. T., Syeda Kausar Anjum


Background: Atherosclerotic cardiovascular diseases are the major causes of mortality and morbidity both in developed and developing countries. High concentrations of lipids in neonates with low gestational age may increase the risk of cardiovascular diseases in the future. It has been suggested that early diagnosis along with appropriate diet and drug therapy may provide an opportunity for long term amelioration of risk factors that contribute to atherosclerosis and cardiovascular diseases in adult life. This study is conducted to compare lipid profile and atherogenic indices in late preterm and term neonates.

Methods: It is a prospective comparative study conducted over a period of 12 months in a tertiary care hospital, Bangalore. A total of 170 neonates between 34 to 42 weeks were included in the study. Umbilical cord blood was collected immediately after delivery and lipid values were measured. Atherogenic indices were calculated.

Results: Out of 170 neonates, 93 (54.7%) were male and 77 (45.3%) were female. 88 (55%) were late preterm and 72 (45%) were term. The cord blood lipid levels were not affected by the gender of the neonates. TG, TC, LDL, VLDL, LDL/HDL, TC/HDL were higher in late preterm babies compared to term babies (p <0.05), HDL levels were not statistically significant. The mean serum lipid levels (TG, TC, LDL and VLDL) and atherogenic indices were higher in SGA babies than AGA, but HDL levels were not statistically significant.

(p >0.05)

Conclusions: Lipid levels are inversely correlated with the gestational age. This could be regarded as a risk factor for development of atherosclerosis and cardiovascular diseases in later life.


Atherogenic indices, Cord blood lipid profile, Late preterm, Term

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World Health Organization. Cardiovascular Diseases (CVDs): Factsheet. 2016. Available at

Barker DJP. Fetal and infant origins of adult disease. Monatsschr Kinderheilkd. 2001;149(1):S2-6.

Freedman DS, Srinivasan SR, Cresanta JL, Webber LS, Berenson GS. Cardiovascular risk factors from birth to 7 years of age: the Bogalusa heart study. serum lipids and lipoproteins. Pediatr. 1987;80:789-96.

Barker DJ, Hales CN, Fall CH, Osmond C, Phipps K,Clark PM. Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidemia (syndrome X): relation to reduced fetal growth. Diabetol.1993;36(1):62-7.

Molina M, Casanueva V, Cid X, Ferrada MC, Pérez R. Lipid profile in newborns with intrauterine growth retardation. Rev Med Chil. 2000;128:741-8.

Orchard TJ. Dyslipoproteinemia and diabetes. Endocrinol Metab Clin North Am. 1992;19:361-80.

Basavaraju SR, Jones TD. Atherosclerotic risks from chemicals: Part 1. Toxicological observations and mechanisms of atherosclerosis. Arch Environ Contam Toxicol. 1998;35(1):152-64.

Parker CR Jr, Carr BR, Simpson ER, MacDonald PC. Decline in the concentration of low-density lipoprotein-cholesterol in human fetal plasma near term. Metabol. 1983;32:919-23.

Meas T. Fetal origins of insulin resistance and the metabolic syndrome: a key role for adipose tissue? Diabetes Metab. 2010;36:11-20.

Tailor PB, Patel SM, Shah CJ, Upadhyay N. Reference range for lipid profile in healthy newborn, infant and LBW newborn. JPSI. 2012;1(4):34-6.

Yip PM, Chan MK, Nelken J, Lepage N, Brotea G, Adeli K. Pediatric reference intervals for lipids and apolipoproteins on the VITROS 5,1 FS chemistry system. Clin Biochem. 2006; 39:978-83.

Jadhao AN, Tadas AK, Tadas SA. Lipid profile of umbilical cord blood of near term and term neonates International. J Current Med Applied Sci. 2014;2(2):01-11.

Pardo IMCG. Atherogenic lipid profile of Brazilian near-term newborns. Braz J Med Biol Res. 2005;38(5):755-60.

Tohmaz U, Raid MR. Cord blood lipid profile. Ir J Neonatol. 2013;4(4):8-10.

Parker Jr CR, Fortunato SJ, Carr BR, Owen J, Hankins GD, Hauth JC. Apo lipoprotein A-1 in umbilical cord blood of newborns: relation to gestational age and high-density lipoprotein cholesterol. Pediatr Res. 1988;23:348-51.

Hamosh M. Lipid metabolism in premature infants. Biol Neonate. 1987;52:50-64.

Nayak CD, Agarwal V, Nayak DM. Correlation of cord blood lipid heterogeneity in neonates with their anthropometry at birth. Indian J Clin Biochem. 2013;28:152-7.

Aletayeb SM, Dehdashtian M, Aminzadeh M, Moghaddam AR, Mortazavi M, Malamiri RA, et al. Correlation between umbilical cord blood lipid profile and neonatal birth weight. Pediatria Polska. 2013;88(6):521-5.

Kenchappa Y, Behera N. Assay of neonatal cord blood lipid levels and its correlation with neonatal gestational age, gender and birth weight: a single center experience. Int J Contemp Pediatr. 2016;3(3):718-24.

Pratinidhi SA, Darawade SP, Seema G, Hegde MV, Naphade PR, Ghadage DP, et al. Study of correlation of cord blood lipids and neonatal anthropometry. Int J Sci Stud. 2015;3(1):99-103.

Kelishadi R, Badiee Z, Adeli K. Cord blood lipid profile and associated factors: baseline data of a birth cohort study. Paediatr Perinat Epidemiol. 2007;21:518-24.

Badiee Z, Kelishadi R. Cord blood lipid profile in a population of Iranian term newborns. Pediatr Cardiol. 2008;29:574-9.