Vitamin D status in asthmatic children and its correlation to asthma control

Sandeep Karanam, Soumya Reddy, Ramesh H.


Background: Asthma is a common chronic inflammatory disease of the airways, affecting around 330 million individuals worldwide. Factors like genetic predisposition, early allergen exposure, diet and vitamin D status are all proposed to influence the development and severity of asthma. Epidemiologic data suggests that low serum vitamin D (<30 ng/mL) in children with asthma is associated with more symptoms and exacerbations. The objectives of this study were to determine serum levels of vitamin D in asthmatic children (6-15 years) and to establish a relation between serum vitamin D levels and asthma control.

Methods: We conducted a cross sectional observational study. A total of 60 children with asthma were studied to know the relationship between serum vitamin D levels and asthma control, assessed according to Global Initiative for Asthma guidelines (GINA).

Results: Only 33.33% of children had sufficient vitamin D levels. Mean±SD vitamin D level of study population was 23.38±8.75. 45% children had well controlled asthma, 28.3% were partly controlled and 26.7% were uncontrolled. Significant (p <0.001) inverse association was found between level of asthma control and vitamin D status. Significant positive correlation was found between percent predicted forced expiratory volume in 1 second and forced vital capacity (P <0.01). Subjects with well controlled asthma had higher serum levels of 25 (OH) D than children with partially controlled or uncontrolled asthma.

Conclusions: Hypovitaminosis D is frequent in children with asthma and is associated with exacerbations, decreased lung functions and severe disease.


Asthma, Asthma control, Hypovitaminosis D, Vitamin D

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