Biochemical and microbiological evaluation of neonatal seizures


  • Bhaskar Reddy A. Assistant Professor, Department of Paediatrics, SVS Medical College, Mahabubnagar, Telangana
  • Ram Mohan G. Senior Resident, Department of Paediatrics, SVS Medical College, Mahabubnagar, Telangana



Neonatal seizures, Biochemical, Microbiological


Background:Neonatal seizure is a common neurological problem in the neonatal period. Neonatal seizures have always been a topic of interest because of their universal occurrence. A varied number of conditions are capable of causing seizures in the neonatal period. The highest incidence of neonatal seizure occurs during first 24 hours of life. The aim was to study biochemical and microbiological factors related with neonatal seizures.

Methods: The present study was conducted in the neonatology unit, department of pediatrics, SVS hospital and medical college. The study was done to assess the biochemical changes and microbilogical organisms implicated in neonatal seizures.

Results:In the present study, out of 1080 babies admitted to neonatology unit during the study period 100 developed seizures giving a hospital incidence of 9.25%. Etilogy in majority of cases of neonatal seizures was hypoxic ischemic encephalopathy (43%). Biochemical changes accounted for 17% of neonatal seizures. Meningitis accounted for 11% of neonatal seizures. The most common organism implicated in neonatal seizures was Escherichia coli (35%).

Conclusions:Biochemical abnormalities may significantly contribute to seizure activity and possibly correction of these abnormalities may play a significant role in seizure control. A biochemical work up is necessary for all cases of neonatal seizures. Appropriate treatment with antibiotics is essential. Examination of cerebrospinal fluid is essential work up in cases of neonatal seizures.


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Original Research Articles