Serum sodium level in dengue infected children: a retrospective study

Reshma Raj, Rashmi Alva


Background: Dengue fever is one of the most common arbo virus mediated outbreaks, being reported from different parts of the world. Now as the outbreaks are hitting different geographic locations, different clinical manifestations are being reported recently. Aim of this study is to document the serum Sodium level in dengue infected children in a tertiary care centre.

Methods: A total 128 cases of NS1 antigen, IgM positive or ELISA positive dengue patients were included in this observational study and analyzed.

Results: The serum Sodium level in dengue varies according to the different groups. In group A (dengue with no warning signs) the serum Sodium level was normal, whereas in case of group B (dengue with warning signs), there was significant hyponatremia. In group C, severe dengue the serum Sodium was normal

Conclusions: Mild hyponatremia is a common electrolyte disturbance in patients with dengue with warning signs. Hence, the lower the serum Sodium levels the higher is the incidence of complications associated with dengue fever.


Dengue, Dengue shock, Hyponatremia

Full Text:



World Health Organization (WHO). Dengue/dengue hemorrhagic fever. Geneva: WHO, 2009. Available at Accessed 13 November 2009.

Tomashek KM, Sharp TM, Margolis HS, Geme SS. Dengue 2016 yellow book/travellers’ health/CDC. Nelson Textbook of Paediatrics. 20th edition. Elsevier; 2016:1629.

Varavithya W, Manu P, Kittikool J, Phongbetchara P, Kashemsant C. Studies on dengue hemorrhagic fever. II: Electrolyte study. J Med Assoc Thai. 1973;56:15-23.

Lumpapong P, Wplong K, Watana V, Thira JP. Electrolyte disturbances and abnormal urine analysis in children with dengue infection. South East Asian J Trop Med Public Health. 2010;41(1):72-6.

Bhagyamma SN, Sreenivasulu U, Prasad SBR, Anuradha R, Durga T. Electrolyte disturbance in dengue infected patients: a hospital-based study. Int J Res Health Sci. 2015;3(1):130-3.

Mekmullica J, Suwanphatra A. Serum and urine Sodium levels in dengue levels; South East Asian J Trop Med Public Health. 2005;36(1):197-9.

Kamath SR, Ranjit S. Clinical features, complications and atypical manifestations of children with severe forms of dengue hemorrhagic fever in South India. Indian J Pediatr. 2006;73(10):889-95.

Schoenfeld R. Electrolyte disturbances in dengue infected patients. Int J Research Health Sci Clin Chem. 1964;10:533.

Panchareon C, Thisyakora U. Neurological manifestations in dengue patients. Southeast Asian J Trop Med Public Health. 2001;32(2):341-5.