Eight year old male with autism spectrum disorder and associated hematuria and nephrolithiasis

Emily Willson, Lavinia Stoicescu, Kapila Seshadri


This is the case of an 8-year-old male of Egyptian descent, with Autism Spectrum Disorder and associated hematuria and nephrolithiasis.  A few relevant case reports of children with autism and comorbid nephrolithiasis have been reported. His case is being reported to draw attention to this particular comorbidity, which may cause other clinicians to report similar cases, and generate an interest in further exploring the renal comorbidities/metabolic correlates of autism.


Autism, Hematuria, Nephrolithiasis

Full Text:



Aggour A, Ziada A, Abdel Hamid A, AbdelRahman S, Morsi A. Metabolic Stone Composition in Egyptian Children. J Pediatr Urol. 2008;5:132-5.

Napoli E, Dueñas N, Giulivi C. Potential therapeutic use of the ketogenic diet in autism spectrum disorders. Front Pediatr. 2014;2:69.

Jia F, Wang B, Shan L, Xu Z, Staal W, Du L. Core Symptoms of Autism Improved after Vitamin D Supplementation. Pediatrics. 2015;135:e196-8.

Luck A, Bobst C, Kaltashov I, Mason A. Human serum transferrin: Is there a link between Autism, high oxalate and iron deficiency anemia? Biochemistry. 2013;52:46.

Reynolds A, Krebs N, Stewart P, Austin H, Johnson S, Withrow N, et al. Iron Status in Children with Autism Spectrum Disorder. Pediatrics. 2012;130:S154-9.

Page T, Coleman M. Purine Metabolism abnormalities in a hyperuricosuria subclass of Autism. Bichim Biophys Acta. 2000;1500:291-6.

Zannoli R, Micheli V, Mazzei M, Sacco P, Piomboni P, Bruni E, et al. Hereditary xanthinuria type II associated with mental delay, autism, cortical renal cysts, nephrocalcinosis, osteopenia, and hair and teeth defects. J Med Genet. 2003;40:121.

Vyas A, White N. Case of Hypercalcemia Secondary to Hypervitaminosis A in a 6-Year-Old Boy with Autism. Case Rep Endocrinol 2011; Article ID 424712.

Kimmoun A, Leheup B, Feillet F, Dubois F, Morali A. Hypercalcemia revealing iatrogenic hypervitaminosis A in a child with autistic troubles. Arch Pediatr. 2008;15:1:29-32.