DOI: http://dx.doi.org/10.18203/2349-3291.ijcp20175126

Relationship between serum zinc levels and simple febrile seizures: hospital based case control study

. Hubaira, Zubir A. Wani, Syed Muneeb R. Qadri

Abstract


Background: Owing to the excessive susceptibility of  the  immature  brain  to temperature, febrile seizures remain one of the common neurological conditions of childhood. Although simple febrile seizures do not pose any increased neurological problems in adult life, but the anxiety, hospitalization and prophylaxis for the episode do call for a genuine concern. A correlation between zinc deficiency and febrile seizures has been proposed and a few studies undertaken have shown mixed conclusions. This case control study was undertaken to compare the serum Zinc levels in patients with simple febrile seizures against the controlled patients with short febrile illness without seizures and to find the correlation if any between simple febrile seizures and serum zinc levels.

Methods: The hospital based, observational case control study was done in Batra Hospital and Medical research Centre, New Delhi. A total of 200 children aged 6 months to 6 years admitted in the hospital with history of short pyrexia (fever for 2 days or less) and fulfilling our inclusion criteria were enrolled for the study after taking an informed consent from their attendants and classified into 2 groups of 100 each as cases and controls. Patients with history of simple febrile seizures as cases and those with fever without seizures as controls. A detailed history was taken, and complete physical examination was done on the patients and recorded on a precoded and pretested proforma. The data was analysed on SPSS 17.

Results: Our results showed a mean of serum zinc levels in cases as 61.53±15.87 mcg/dl which was found to be lower compared to controls as 71.90+18.50 mcg /dl. Further the difference was found to be statistically significant (P<0.05).

Conclusions: Low serum zinc levels in the patients of simple febrile seizures in association with other risk factors may enhance the occurrence of seizures triggered by fever. Thus, a possible correlation exists between the mean serum zinc level and simple febrile seizures.


Keywords


GABA, Hypozincemia, NMDA, Simple febrile seizures, Serum zinc levels

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References


Holtzman D, Obana K, Olson J. Hyperthermia-induced seizures in the rat pup: a model for febrile convulsions in children. Science. 1981;213(4511):1034-6.

Tsai FJ, Hsieh YY, Chang CC. Polymorphisms for interleukin I beta exon 5 and interleukin 1 receptor antagonist in Taiwanese children with febrile convulsions. Arch Pediatr Adolesc Med. 2002;156(6):545-8.

Virta M. Hurme M, Helminen M. Increased plasma levels of pro- and anti-inflammatory cytokines in patients with febrile seizures. Epilepsia. 2002;43(8):920-3.

Kumari PL, Nair MK, Nair SM, Kailas L, Geetha S. Iron deficiency as a risk factor for simple febrile seizures - a case control study. Indian Pediatr. 2011;49(1):17-9.

Amiri M, Farzin L, Moassesi ME, Sajadi F. Serum trace element levels in febrile convulsion. Biol Tr Elem Res. 2010;135(1):38-44.

Ebadi M, Wilt 5, Ramaley R. The role of zinc and zinc-binding proteins in regulation of glutamic acid decarboxylase in brain. Chemical and biological aspects of vitamin B6, Catalysis. New York: Alan R Liss;1984:255-275.

Cossart R, Bernard C, Ben-Ari Y. Multiple facets of GABAergic neurons and synapses: multiple fates of GABA signalling in epilepsies. Trends Neurosci. 2005;28(2):108-15.

Macdonald RL, Kang JQ. Molecular pathology of genetic epilepsies associated with GABAA receptor subunit mutations. Epilepsy Curr. 2009;9(1):18-23.

Ehsani F, Vahid-Harandi M, Kany K. Determination of serum Zinc in children affected by febrile convulsion and comparison with control group. J Iranian Med Sci Univ. 2006;12:219-76.

Margaretha L, Masloman N. Correlation between serum Zinc level and simple febrile seizure in children. Pediatr Indones. 2010;50(6):326-30.

Aly IA, Kmal HM, Soliman DR, Mohamed MH. Iron profile parameters and serum zinc and copper levels in children with febrile convulsions in Banha. J Am Sci. 2014;10(7):320-7.

Mahyar A, Pahlavan A, Varasteh-Nejad A. Serum zinc level in children with febrile seizure. Acta Medica Iranica. 2008;46(6):477-80.

Kafadar I, Akıncı AB, Pekun F, Adal E. The role of serum zinc level in febrile convulsion etiology. J Pediatr Inf. 2012 Aug 3;6(3):90-3.

World Health Organization and United Nations Children Fund. Clinical management of acute diarrhoea. WHO/UNICEF Joint Statement; 2004;8(3):237-41. Available at http://apps.who.int/iris/bitstream/10665/68627/1/WHO_FCH_CAH_04.7.pdf

Günduz Z, Yavuz I, Koparal M, Kurnanda S. Saraymen R. Serum and cerebrospinal fluid zinc levels in children with febrile convulsions. Acta Paediatr Jpn. 1996;38(3):273-41.

Mahyar A, Pahlavan A, Varasteh-Nijad A. Serum zinc level in children with febrile seizure. Acta Medica Iranica. 2008;46(6):67-9.

Ganesh R, Janakiraman L. Serum zinc levels in children with simple febrile seizure. Clin Pediatr (Phila). 2008;47(2):164-6.

Kafadar I, Akini AB, Pekun F, Ada E. The role of serum zinc level in febrile convulsion etiology. J Pediatr Inf. 2012;6:90-3.

Talebian A, Vakili Z. Talar SA, Kazerni M. Mousavi GA. Assessment of the relation between serum Zinc and magnesium levels in children with febrile convulsion. Iranian J Pathol. 2009;4:157-60.

Barhanoglu M, Tutuncuoglu 5, Coker C, Tekgul H, Ozgur T. Hypo Zincaemia in febrile convulsion. Eur J Pediatr. 1996;155(6):498-501.