Seizures as an unusual presentation of neonatal lupus erythematosus: a case report

Authors

  • Maheshwar Gunawat Department of RNT Medical College, Udaipur, Rajasthan
  • Neeraj Kumar Department of RNT Medical College, Udaipur, Rajasthan
  • Lakhan Poswal Department of RNT Medical College, Udaipur, Rajasthan

DOI:

https://doi.org/10.18203/2349-3291.ijcp20162404

Keywords:

NLE, Hypopigmented-hyperpigmented skin lesion, Seizures.

Abstract

Neonatal lupus erythematosus is an uncommon passive autoimmune disease manifesting as cutaneous lupus lesions and/or congenital heart blocks with rare CNS involvement. A 2months old female infant admitted for respiratory illness was found to have neonatal lupus skin lesions, developed seizures during hospital stay without any metabolic cause or CNS infection. Mother had significantly raised anti-Ro/SSA and anti-La/SSB antibodies. As per classical description, the cutaneous lesions started to fade but the CNS involvement needs follow up. NLE should be suspected on the basis of cutaneous lesions even in absence of heart block and seizures may also rarely manifest.

References

Burch JM, Lee LA, Weston WL. Neonatal lupus erythematosus. Dermatol Nur. 2002;14:157-60.

Franco HL, Weston WL, Peebles C. Autoantibodies directed against sicca syndrome antigen in neonatal lupus syndrome. J Am Acad Dermatol. 1981;4:67.

Kephardt D, Hood AF, Provost TT. Neonatal lupus erythromatosus: new serologic findings. J Invest Dermtol. 1981;77:131.

Weston WL, Harmon C, Peebles C, Manchester D. A serologic marker for neonatal lupus erythematosus. Br J Dermatol. 1982;107:377-82.

Lee LA. The clinical spectrum of neonatal lupus. Arch Dermatol Res. 2008;301:107.

Lee LA. Transient autoimmunity related to maternal autoantibodies: Neonatal lupus. Autoimmune Rev. 2005;4:207.

Boh EE. Neonatal lupus erythematosus. Clin Dermatol. 2004;22:125.

Kaye EM, Butler IJ, Conley S. Myelopathy in neonatal and infantile lupus erythematosus. J Neurol Neurosurg Psychiatry. 1987;50:923-6.

Cabanas F, Pellicer A, Valverde E, Morales C, Quero J. Central nervous system vasculopathy in neonatal lupus erythematosus. Pediatr Neurol. 1996;15:124-6.

Cabral DA, Mehta S, Julie P, Michael S. Abnormal central nervous system (CNS) imaging studies in neonatal lupus erythematosus (NLE). Arthritis Rheum. 1999;42 (Suppl):S180.

Sheng-Chieh L, Shyh-Dar S, Li-Hsin-Huang. Focal Seizures as an Unusual Presentation of Neonatal Lupus Erythematosus. Asian Pacific Journal of Allergy And Immunology. 2005;23:61-4.

Downloads

Published

2016-12-21